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In this article, we report a case of signet ring cell carcinoma of the ampulla of Vater showing focal neuroendocrine amphicrine differentiation and intestinal phenotype, which occurred in a 49-year-old male who is still alive 7 years after surgery, without evidence of recurrence. This long-term survival might be attributed not only to the early stage of the disease but also to the neuroendocrine differentiation and the absence of genetic alterations.<\/jats:p>","DOI":"10.1177\/1066896918784666","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T01:09:44Z","timestamp":1531357784000},"page":"89-93","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Signet Ring Cell Carcinoma of the Ampulla of Vater With Focal Neuroendocrine Differentiation of the Amphicrine Type: Report of a Case With Long-Term Survival"],"prefix":"10.1177","volume":"27","author":[{"given":"Adele","family":"Fornelli","sequence":"first","affiliation":[{"name":"Unit of Anatomic Pathology, Ospedale Maggiore, Bologna, 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