{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:25:56Z","timestamp":1777717556774,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Hodgkin\/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (CHL) are of B-cell origin. In a small number of CHL cases, the tumor cells can express T-cell antigens. CD8 expression in this setting is extremely rare. We identified 5 cases of CHL with aberrant CD8 expression from our database. The patients included 3 men and 2 women with a median age of 33 years (range = 20-59 years). All the patients initially presented with lymphadenopathy and variable number of RS cells. Two cases were classified as mixed cellularity type that showed prominent vascular proliferation mimicking peripheral T-cell lymphoma. Two cases represented nodular sclerosis type. The tumor cells in all cases were positive for CD8 and negative for CD2, CD3, CD4, and CD7 and carried germline T-cell receptor genes. Molecular studies revealed T-cell receptor genes to be in germline configuration in 4 cases with available information. Given the morphologic overlap with peripheral T-cell lymphoma and the rarity of this type of CHL, identifying more cases will help our better understanding of this entity.<\/jats:p>","DOI":"10.1177\/1066896918790384","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T05:41:16Z","timestamp":1532929276000},"page":"166-173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Classical Hodgkin Lymphoma With Aberrant CD8 Expression: A Clinicopathologic Study of Five Cases"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-5695","authenticated-orcid":false,"given":"Neda","family":"Mirzamani","sequence":"first","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Lake Success, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-018X","authenticated-orcid":false,"given":"Xinmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Lake Success, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Brody","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Lake Success, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia G.","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiz","family":"Sen","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peihong","family":"Hsu","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Lake Success, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"bibr1-1066896918790384","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61245"},{"key":"bibr2-1066896918790384","doi-asserted-by":"publisher","DOI":"10.7150\/jca.13107"},{"key":"bibr3-1066896918790384","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092209"},{"key":"bibr4-1066896918790384","unstructured":"Swerdlow SH, Campo E, Harris NL, et al. 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