{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:16:01Z","timestamp":1781093761956,"version":"3.54.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Supratentorial ependymomas (ST EPNs) are molecularly characterized, of which the RELA fusion positive tumors are the most common and aggressive subgroup. Moreover, histologically, anaplastic ST EPN (ST-AE) often mimic other central nervous system primary high-grade tumors resulting in a diagnostic dilemma. We aimed to study a cohort of ST-AE; evaluate the expression of two RELA fusion-associated markers\u2014L1CAM and p65 (NF-\u03baB); and correlate their expression with clinical and histological parameters. Cases of ST-AE diagnosed in our department from January 2011 to June 2016 (n = 72) were reviewed. A battery of immunohistochemical markers was employed. A total of 65 confirmed ST-AE were included in the study. Age ranged from 9 months to 60 years. There was a slight predominance in the pediatric population (57%). Male-to-female ratio was 1:1.16. Histomorphological features were varied and mimicked other high-grade tumors in several cases. L1CAM immunopositive tumors constituted 26% of cases and were predominantly seen in young children, in the frontoparietal location, and exhibited clear cell morphology with calcification. A consistent pattern of L1CAM immunopositivity was noted in paired primary and recurrent tumor samples. Our study portrays the varied clinical and histomorphological spectrum of ST-AE. The study emphasizes the association of L1CAM immunopositivity with a wide spectrum of histological parameters, literature on which is scant till date. Since ST EPN-RELA are tumors with aggressive behavior, such a correlation would be clinically relevant, particularly when there is limited access to molecular testing.<\/jats:p>","DOI":"10.1177\/1066896918800812","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T05:08:01Z","timestamp":1537852081000},"page":"251-258","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["L1CAM Immunopositivity in Anaplastic Supratentorial Ependymomas: Correlation With Clinical and Histological Parameters"],"prefix":"10.1177","volume":"27","author":[{"given":"Pooja","family":"Chavali","sequence":"first","affiliation":[{"name":"National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-6557","authenticated-orcid":false,"given":"Shilpa","family":"Rao","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravya","family":"Palavalasa","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandeesh","family":"Bevinahalli","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasha T. C.","family":"Muthane","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishanth","family":"Sadashiva","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-2359","authenticated-orcid":false,"given":"Vani","family":"Santosh","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"bibr1-1066896918800812","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0833"},{"key":"bibr2-1066896918800812","doi-asserted-by":"publisher","DOI":"10.1038\/nature13109"},{"key":"bibr3-1066896918800812","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. 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