{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:14:56Z","timestamp":1777716896008,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>IgG4-related disease is a recent entity that has been described in a wide variety of organ systems. A 46-year-old female presented with acute appendicitis accompanied by a mass-forming lesion, raising a concern for neoplasm, and therefore, hemicolectomy was performed. The lesion revealed a dense lymphoplasmacytic infiltrate accompanied by storiform fibrosis and obliterative phlebitis. The IgG4\/IgG plasma cell ratio was &gt;50%, and the number of IgG4-positive plasma cells was &gt;100\/high-power field. In order to assess the IgG4\/IgG plasma cell ratio, MUM1 was employed instead of IgG to successfully estimate the plasma cell concentration. There was also a concomitant hyperplasia of S100-positive cell, which could represent dendritic or Schwannian origin and possibly play a pathophysiologic role. The hyperplasia was significant by itself that it may mimic a mass-forming lesion. This newly described entity of the past decade deserves increased recognition due to clinical implication and surgical morbidity. This is the first case of IgG4-related disease in the appendix to our knowledge that fully satisfied all the pathological diagnostic criteria. We would like to also highlight our innovative approach of evaluating the IgG4\/IgG plasma cell.<\/jats:p>","DOI":"10.1177\/1066896919830213","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T05:47:23Z","timestamp":1550468843000},"page":"541-546","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["IgG4-Related Appendiceal Disease: A First Case Report Fulfilling All Pathological Diagnostic Criteria and With Concomitant S100-Positive Dendritic\/Schwann Cell Hyperplasia"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-9175","authenticated-orcid":false,"given":"Dong Hyang","family":"Kwon","sequence":"first","affiliation":[{"name":"Georgetown University Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaskar","family":"Kallakury","sequence":"additional","affiliation":[{"name":"Georgetown University Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"DeBrito","sequence":"additional","affiliation":[{"name":"Georgetown University Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Azumi","sequence":"additional","affiliation":[{"name":"Georgetown University Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,2,17]]},"reference":[{"key":"bibr1-1066896919830213","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"bibr2-1066896919830213","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"bibr3-1066896919830213","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283413469"},{"key":"bibr4-1066896919830213","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90087-6"},{"key":"bibr5-1066896919830213","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"bibr6-1066896919830213","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"bibr7-1066896919830213","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1507-0"},{"key":"bibr8-1066896919830213","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2016.17.1.56"},{"key":"bibr9-1066896919830213","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3636-2"},{"key":"bibr10-1066896919830213","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2017.18.6.1012"},{"key":"bibr11-1066896919830213","unstructured":"Mayo Clinic. 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