{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:16:55Z","timestamp":1777717015130,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Metastatic breast cancer resembling ductal carcinoma in situ (DCIS) is a rare phenomenon. In this article, we present a unique case of metastatic lobular carcinoma with DCIS-like morphology in the left axillary lymph nodes of a 52-year-old female. She presented with 2 lesions in the left breast on mammography, and a mastectomy with axillary lymph node dissection was performed. Gross examination showed a 3.5 \u00d7 2.5 \u00d7 1.0 cm indistinct tumor in the lower outer quadrant and a 2.5 \u00d7 2.5 \u00d7 1.8 cm tumor in the upper outer quadrant. Microscopic assessment revealed a pleomorphic lobular carcinoma in the lower outer quadrant and a grade 2 invasive ductal carcinoma in the upper outer quadrant. Sixteen of the 17 axillary lymph nodes showed metastatic lobular carcinoma with foci of solid and comedo-type DCIS-like features. Immunohistochemical analysis of the primary and metastatic lobular carcinoma showed no expression of E-cadherin and p63 antibodies. To our knowledge, metastatic lobular carcinoma exhibiting this pattern has not been reported. The case suggests that lobular carcinoma can morphologically recreate a primary microenvironment at a distant site and simulate in situ growth. Recognition of this pattern is important to avoid misdiagnosis.<\/jats:p>","DOI":"10.1177\/1066896919888744","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T07:59:05Z","timestamp":1575273545000},"page":"436-439","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Metastatic \u201cDuctal Carcinoma In Situ\u2013Like\u201d Lobular Carcinoma in a Lymph Node: A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-962X","authenticated-orcid":false,"given":"Sidiq","family":"Tijani","sequence":"first","affiliation":[{"name":"North Tyneside General Hospital, North Shields, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirti","family":"Sharma","sequence":"additional","affiliation":[{"name":"North Tyneside General Hospital, North Shields, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Yuen","sequence":"additional","affiliation":[{"name":"The Whittington Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer","family":"Shaaban","sequence":"additional","affiliation":[{"name":"Queens Elizabeth Hospital, Birmingham, UK"},{"name":"University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,1]]},"reference":[{"key":"bibr1-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.8.797"},{"key":"bibr2-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.4.380"},{"key":"bibr3-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199710)183:2<188::AID-PATH898>3.0.CO;2-7"},{"key":"bibr4-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033706"},{"key":"bibr5-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1177\/1066896911435724"},{"key":"bibr6-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2004.08.006"},{"key":"bibr7-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2018-205079"},{"key":"bibr8-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-1-83"},{"key":"bibr9-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1111\/his.12353"},{"key":"bibr10-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4898-4"},{"key":"bibr11-1066896919888744","doi-asserted-by":"publisher","DOI":"10.1177\/1066896918763899"},{"key":"bibr12-1066896919888744","first-page":"40","volume-title":"WHO Classification of Tumours of the Breast","author":"Lakhani SR","year":"2012","edition":"4"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896919888744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896919888744","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896919888744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:20:57Z","timestamp":1777458057000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896919888744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,1]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1177\/1066896919888744"],"URL":"https:\/\/doi.org\/10.1177\/1066896919888744","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,1]]}}}