{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:43:42Z","timestamp":1792442622530,"version":"4.5.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>This report describes clinicopathologic findings from the case of a patient with a breast mass that was ultimately diagnosed as a metastatic high-grade endometrioid carcinoma of endometrial origin. The breast lesion as well as the solid areas of the endometrial lesion displayed a similar immunoprofile: GATA3-positive; synaptophysin positive; negative for mammaglobin, gross cystic disease fluid protein-15, chromogranin, estrogen receptor, progesterone receptor, and HER2\/neu; and intact expression of the DNA mismatch repair proteins MLH1, MSH2, MSH6, and PMS2. The breast lesion was negative for PAX-8, whereas the solid areas of the endometrial lesion showed focal weak positivity. A review of the literature on GATA-3 expression in endometrial carcinomas found a reported frequency of expression that ranged from 0% to 13% of cases, typically in a patchy, focal, and generally restricted pattern. However, GATA-3 may be diffusely expressed in high-grade endometrial carcinomas. Since the potential for PAX-8 expression to be lost in high-grade endometrioid carcinomas is well known, a GATA-3-positive\/PAX8-negative immunoprofile may be encountered in high-grade endometrioid carcinomas of the endometrium, and this composite immunoprofile is a potential diagnostic pitfall when such a lesion is being evaluated in a breast metastasis.<\/jats:p>","DOI":"10.1177\/1066896920913114","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T04:21:29Z","timestamp":1584591689000},"page":"631-636","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["High-Grade Endometrioid Carcinoma of the Endometrium With a GATA-3-Positive\/PAX8-Negative Immunophenotype Metastatic to the Breast: A Potential Diagnostic Pitfall"],"prefix":"10.1177","volume":"28","author":[{"given":"Christine","family":"Salibay","sequence":"first","affiliation":[{"name":"University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8017-2854","authenticated-orcid":false,"given":"Oluwole","family":"Fadare","sequence":"additional","affiliation":[{"name":"University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"key":"bibr1-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.048"},{"key":"bibr2-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP5UAFMSA9ZQBZ"},{"key":"bibr3-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213438.01278.5f"},{"key":"bibr4-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.11.003"},{"key":"bibr5-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000505"},{"key":"bibr6-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2016.09.011"},{"key":"bibr7-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP8H2VBDSCIOBF"},{"key":"bibr8-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182a0218f"},{"key":"bibr9-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000167"},{"key":"bibr10-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000541"},{"key":"bibr11-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000491"},{"key":"bibr12-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2019.02.003"},{"key":"bibr13-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.043"},{"key":"bibr14-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc1038"},{"key":"bibr15-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31814b26fe"},{"key":"bibr16-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.191"},{"key":"bibr17-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011101)92:9<2259::AID-CNCR1571>3.0.CO;2-O"},{"key":"bibr18-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197206)29:6<1691::AID-CNCR2820290637>3.0.CO;2-4"},{"key":"bibr19-1066896920913114","first-page":"49","volume":"179","author":"Chaignaud B","year":"1994","journal-title":"J Am Coll Surg"},{"key":"bibr20-1066896920913114","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21453"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896920913114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896920913114","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896920913114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:12Z","timestamp":1777458072000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896920913114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,19]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1177\/1066896920913114"],"URL":"https:\/\/doi.org\/10.1177\/1066896920913114","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,19]]}}}