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We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with no invasive carcinoma in the underlying sebaceous glands. Early stromal invasion was identified that featured 2 distinctive but focally intermixed populations of sebaceous carcinoma cells and squamous carcinoma cells. The 2 populations of cells exhibited their respective distinct immunophenotype but both showed strong overexpression of p53. This case provides evidence to support the hypothesis that some ocular sebaceous carcinoma may arise from intraepithelial pluripotent stem cells.<\/jats:p>","DOI":"10.1177\/1066896920917445","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T05:12:27Z","timestamp":1588569147000},"page":"888-892","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Ocular Sebaceous Carcinoma In Situ With Biphenotypic Differentiation: A Reappraisal of the Alternative Origin of the Tumor"],"prefix":"10.1177","volume":"28","author":[{"given":"C. L.","family":"Yim","sequence":"first","affiliation":[{"name":"Hong Kong Eye Hospital, Kowloon, Hong Kong SAR, China"},{"name":"Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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