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We present a case of primary amelanotic malignant melanoma of the urethra in a male, with clinical and histological characteristics that could have led to a mistaken diagnosis of high-grade urothelial carcinoma. Amelanotic mucosal melanoma should be suspected in all cases of high-grade mucosal tumors with practically any appearance (epithelioid, sarcomatoid, anaplastic, mixed). Morphological hints pointing toward melanoma\u2014such as the presence of sparse melanin pigment or melanoma in situ\u2014should be sought, and if absent, an immunohistochemical panel comprising S100 and HMB45 should be performed.<\/jats:p>","DOI":"10.1177\/1066896920919497","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T01:30:36Z","timestamp":1589160636000},"page":"510-513","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Amelanotic Malignant Melanoma of the Male Urethra: A Potential Diagnostic Pitfall"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-3869","authenticated-orcid":false,"given":"Alessandro","family":"Caputo","sequence":"first","affiliation":[{"name":"University of Salerno, Salerno, 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