{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:02:14Z","timestamp":1791234134236,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Primary urethral adenocarcinomas are very rare neoplasms accounting for &lt;10% of all urethral carcinomas. Site of their origin is unclear, but they seem to arise from Skene\u2019s paraurethral glands, which is the female homologue of the male prostate. The aim of this article is to report the first case of Skene\u2019s gland adenocarcinoma in which a molecular genetic profiling was performed. The patient was a 73-year-old woman with a polypoid lesion sized 3 \u00d7 2 cm located at the interface between the bladder neck and the proximal urethra. Transurethral resection was performed and small tissue fragments with positive margins were obtained. Histology revealed an epithelial neoplasm consisting of cribriform structures located in the subepithelial connective tissue of the bladder wall and proximal urethra. The lesion showed positive immunohistochemical staining with prostate specific antigen, prostatic acid phosphatase, NKX3.1, and alpha-methylacyl-CoA racemase. Using the Illumina TruSight Tumor 170 next-generation sequencing assay, a mutation and loss of heterozygosity of the phosphatase and tensin homologue ( PTEN) gene was detected. No fusion in any of the examined genes was found using this assay as well as FusionPlex Solid Tumor Kit and FusionPlex Sarcoma kit assays from ArcherDX. Given the rarity of Skene\u2019s gland adenocarcinoma, it is uncertain whether the same grading and prognostic criteria that are currently used for prostatic cancer apply here as well. It is also unclear what treatment strategy should be applied, but according to the available literature, it seems that local excision or wide surgical resection could represent sufficient therapeutic modalities.<\/jats:p>","DOI":"10.1177\/1066896920947808","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T12:24:53Z","timestamp":1597407893000},"page":"447-453","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["First Molecular Genetic Characterization of Skene\u2019s Gland Adenocarcinoma"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-5538","authenticated-orcid":false,"given":"Ji\u0159\u00ed","family":"Lenz","sequence":"first","affiliation":[{"name":"Department of Pathology, Znojmo Hospital, Czech Republic"},{"name":"Cytohisto s.r.o., Breclav, Czech Republic"},{"name":"Department of Anatomy, Histology and Embryology, Faculty of 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Charles University, Pilsen, Czech Republic"},{"name":"Bioptical Laboratory Ltd., Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Kone\u010dn\u00e1","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lenz","sequence":"additional","affiliation":[{"name":"Cytohisto s.r.o., Breclav, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"bibr1-1066896920947808","volume-title":"WHO Classification of Tumours of the Urinary System and Male Genital Organs","author":"Moch 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