{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:20:21Z","timestamp":1777717221147,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n                    Thymic typical and atypical carcinoids are rare and appear to be more aggressive than similar tumors in other sites. We retrospectively analyzed a group of biomarkers that hold therapeutic and prognostic utility, in 27 of these tumors. All cases were immunohistochemically stained with PAX5, MET, CRMP5, paxillin, p21, p27, EZH2, PDL-1, and Ki-67, and then H-scored. Clinicopathologic and survival data were statistically analyzed against staining (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    test). Five- and 10-year-survival rates were 53% and 18%, respectively. Mitotic counts \u22654 per 2 mm\n                    <jats:sup>2<\/jats:sup>\n                    and tumor size \u22655 cm, associated with death of disease (DoD; P = .010 and .016). Ki-67 expression \u22651% associated with DoD ( P = .003) and death within 5 years ( P = .031). Biomarkers stained tumor cases as follows: PDL-1 = 0%, PAX-5 = 0%, MET = 7.4%, paxillin = 41%, CRMP5 = 78%, p21 = 63%, p27 = 63%, EZH2 = 37%, and MASH1 = 59%. Overall \u00b1 staining did not associate with survival or grade. Cases with low CRMP5 H-scores (&lt;80) associated with DoD ( P = .002), while CRMP5 H-scores &gt;80 associated with 10-year survival ( P = .022). Cases with high MASH1 H-score (&gt;100) associated with DoD ( P = .021). Accurate grading and staging remain paramount in predicting clinical outcome. Biomarkers may have significance in subsets of patients and the use of these studies likely should be focused on a more personalize type of approach.\n                  <\/jats:p>","DOI":"10.1177\/1066896920976845","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T04:58:56Z","timestamp":1606453136000},"page":"358-367","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Typical and Atypical Carcinoid Tumors of the Mediastinum: A Biomarker Analysis of 27 Cases With Clinical Correlation"],"prefix":"10.1177","volume":"29","author":[{"given":"Michael","family":"Zaleski","sequence":"first","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Kalhor","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-5713","authenticated-orcid":false,"given":"Cesar A.","family":"Moran","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"bibr1-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.08.013"},{"key":"bibr2-1066896920976845","first-page":"551","volume":"108","author":"Huntrakoon M","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"bibr3-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197204)29:4<1075::AID-CNCR2820290457>3.0.CO;2-O"},{"key":"bibr4-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1136\/thx.29.5.553"},{"key":"bibr5-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70409-9"},{"key":"bibr6-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.04.015"},{"key":"bibr7-1066896920976845","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.08.20"},{"key":"bibr8-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31815eb7a2"},{"key":"bibr9-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.09.058"},{"key":"bibr10-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2006.02.007"},{"key":"bibr11-1066896920976845","doi-asserted-by":"publisher","DOI":"10.5858\/2009-0664-OAR1.1"},{"key":"bibr12-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817dc37c"},{"key":"bibr13-1066896920976845","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11121902"},{"key":"bibr14-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-19-0372"},{"key":"bibr15-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1159\/000493348"},{"key":"bibr16-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2020.06.002"},{"key":"bibr17-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00876-8"},{"key":"bibr18-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-001649"},{"key":"bibr19-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"bibr20-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.7609"},{"key":"bibr21-1066896920976845","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00204"},{"key":"bibr22-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1836"},{"key":"bibr23-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-14-0983"},{"key":"bibr24-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076997"},{"key":"bibr25-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2156"},{"key":"bibr26-1066896920976845","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_98_17"},{"key":"bibr27-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2004.04.007"},{"key":"bibr28-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.23.4139"},{"key":"bibr29-1066896920976845","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-2012-0269"},{"key":"bibr30-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000647"},{"key":"bibr31-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2341"},{"key":"bibr32-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-013-0085-4"},{"key":"bibr33-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21668"},{"key":"bibr34-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4036"},{"key":"bibr35-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1385\/EP:14:2:133"},{"key":"bibr36-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.118"},{"key":"bibr37-1066896920976845","doi-asserted-by":"publisher","DOI":"10.3390\/cells6030026"},{"key":"bibr38-1066896920976845","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0489-OA"},{"key":"bibr39-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.11.013"},{"key":"bibr40-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04032.x"},{"key":"bibr41-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(20010201)49:2<146::AID-ANA34>3.0.CO;2-E"},{"key":"bibr42-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.138016"},{"key":"bibr43-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0900-4"},{"key":"bibr44-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0085-1"},{"key":"bibr45-1066896920976845","first-page":"5441","volume":"57","author":"Katayose Y","year":"1997","journal-title":"Cancer Res"},{"key":"bibr46-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0472"},{"key":"bibr47-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.038976"},{"key":"bibr48-1066896920976845","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.08.82"},{"key":"bibr49-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3180ca8a49"},{"key":"bibr50-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.039917"},{"key":"bibr51-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000155162.33044.4f"},{"key":"bibr52-1066896920976845","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90248-9"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896920976845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896920976845","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896920976845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:35Z","timestamp":1777458095000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896920976845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,27]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1177\/1066896920976845"],"URL":"https:\/\/doi.org\/10.1177\/1066896920976845","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,27]]}}}