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In this article, we describe a case of primary CCS-GI that occurred in the ileum of a 65-year-old male to further illustrate its rare occurrence. Similar to CCS of soft tissue (CCS-ST), the tumor was composed of spindled to epithelioid cells displaying fascicular, nested, or pseudopapillary arrangement. The tumor cells had large round to ovoid nuclei with vesicular chromatin and prominent nucleoli, containing eosinophilic to pale cytoplasm. In contrast to CCS-LT\/MGNET, immunohistochemical study also showed variable positivity of HMB45, melan A, and MiTF besides the strong and diffuse staining of S100 protein and SOX10. Fluorescence in situ hybridization (FISH) using fusion probes identified EWSR1 and ATF1 genes rearrangement. Next-generation sequencing (NGS) analysis further revealed EWSR1 exons9\/8- ATF1 exon4 and ATF1 exon3- EWSR1 exon11 fusion genes. CCS-GI and CCS-LT\/MGNET possibly represent 2 related entities of the same spectrum, which differentiate along 2 different pathways.<\/jats:p>","DOI":"10.1177\/1066896920985311","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T19:30:04Z","timestamp":1610566204000},"page":"677-684","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary Clear Cell Sarcoma of the Ileum: A Case Report With Next-Generation Sequencing Analysis"],"prefix":"10.1177","volume":"29","author":[{"given":"Peipei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 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