{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:20:55Z","timestamp":1777717255653,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    Anaplastic lymphoma kinase (ALK) rearrangement-associated renal cell carcinoma (\n                    <jats:italic>ALK<\/jats:italic>\n                    -rearranged RCC) is a new provisional entity that has been included in the 2016 World Health Organization classification of RCCs. We report 2 cases of\n                    <jats:italic>ALK<\/jats:italic>\n                    -rearranged RCC, 1 with a vinculin-ALK (\n                    <jats:italic>VCL-ALK<\/jats:italic>\n                    ) fusion and the other with an\n                    <jats:italic>EML4-ALK<\/jats:italic>\n                    fusion. The\n                    <jats:italic>VCL-ALK<\/jats:italic>\n                    RCC occurred in a 14-year-old girl with sickle cell trait and showed features similar to previously described\n                    <jats:italic>VCL-ALK<\/jats:italic>\n                    RCCs, including medullary epicenter, solid architecture, and polygonal cells with cytoplasmic vacuoles. The\n                    <jats:italic>EML4-ALK<\/jats:italic>\n                    RCC occurred in a 14-year-old boy with no evidence of sickle cell trait and had multiple less-specific growth patterns comprising tubular, solid, and tubulopapillary architectures in the desmoplastic stroma, reminiscent of collecting duct carcinoma. Both tumors demonstrated cytoplasmic and membranous ALK protein expression by immunohistochemistry. Fluorescence in situ hybridization confirmed the\n                    <jats:italic>ALK<\/jats:italic>\n                    gene rearrangements in both cases. On review in the literature, we found that solid architecture and cytoplasmic vacuoles were present significantly more frequently in\n                    <jats:italic>VCL-ALK<\/jats:italic>\n                    RCC than in non-\n                    <jats:italic>VCL-ALK<\/jats:italic>\n                    RCC, supporting the distinctive nature of the former.\n                  <\/jats:p>","DOI":"10.1177\/10668969211003660","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T12:32:53Z","timestamp":1615984373000},"page":"808-814","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["<i>ALK<\/i>\n                    -rearranged Renal Cell Carcinoma (RCC): A Report of 2 Cases and Review of the Literature Emphasizing the Distinction Between\n                    <i>VCL-ALK<\/i>\n                    and Non-\n                    <i>VCL-ALK<\/i>\n                    RCC"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-698X","authenticated-orcid":false,"given":"Sintawat","family":"Wangsiricharoen","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarangarajan","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Matoso","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedram","family":"Argani","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.213"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20839"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000179"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/PO.18.00185"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.152651"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.107"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27391"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.07.015"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.07.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000610"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22346"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22382"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13185"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12592"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0488"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2017.11.010"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.03.032"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0879-0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02752-5"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","unstructured":"Kuroda N Trpkov K Gao Y et al. ALK Rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1 KIF5B and KIAA1217. Mod Pathol. Published online 2020;33:2564-2579. doi:10.1038\/s41379-020-0578-0","DOI":"10.1038\/s41379-020-0578-0"},{"key":"e_1_3_2_22_2","first-page":"817","article-title":"Identification of anaplastic lymphoma kinase fusions in clear cell renal cell carcinoma","volume":"43","author":"Chen W","year":"2020","unstructured":"Chen W, Li W, Bai B, Wei H. Identification of anaplastic lymphoma kinase fusions in clear cell renal cell carcinoma. Oncol Rep. 2020;43:817-826. doi:10.3892\/or.2020.7462","journal-title":"Oncol Rep"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2020.61.3.262"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.144"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13131"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969211003660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969211003660","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969211003660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:40Z","timestamp":1777458100000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969211003660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1177\/10668969211003660"],"URL":"https:\/\/doi.org\/10.1177\/10668969211003660","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,17]]}}}