{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:21:04Z","timestamp":1777717264230,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Basic Public Welfare Research Project of Zhejiang Province","award":["LGD19H160004"],"award-info":[{"award-number":["LGD19H160004"]}]},{"name":"the Basic Public Welfare Research Project of Zhejiang Province","award":["LGF21H030005"],"award-info":[{"award-number":["LGF21H030005"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Sarcomatoid malignant mesothelioma (MM) is a rare and aggressive disease, and its diagnosis is challenging. A 60-year-old man presented with a recurrent subcutaneous mass in his right back after the initial resection. A chest computed tomography (CT) scan found right pleural thickening, nodular pleural thickening, pleural effusion, mediastinal, and right infraclavicular lymph nodes enlargement, which indicated a right pleura MM. Immunohistochemical stains of the resected mass showed sarcomatous atypical spindle cells, which were positive for pan-CKs (clone Anti-cytokeratin cocktail AE1\/AE3), cytokeratin 5\/6 (CK5\/6), Wilm\u2019s tumor 1, podoplanin, vimentin and programmed death-ligand 1 (PD-L1), and negative for Napsin A, thyroid transcription factor 1, CDX 2, calretinin and desmin, and fluorescent in situ hybridization detected homozygous p16\/cyclin-dependent kinase inhibitor 2A ( p16\/CDKN2A) deletion. The association of the chest CT features and the pathological assessment confirmed metastatic MM in the subcutaneous layer of the back. Moreover, positron emission tomography\u2013CT showed multiple metastases in his brain. He developed massive right pleural effusion and chest tightness soon, and the mass kept growing despite local and systemic treatments. The patient die of pulmonary failure in 3 months.<\/jats:p>","DOI":"10.1177\/10668969211005094","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T12:38:52Z","timestamp":1615984732000},"page":"856-863","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Metastasis of Sarcomatoid Malignant Mesothelioma With\n                    <i>p16\/CDKN2A<\/i>\n                    Deletion Manifested as a Subcutaneous Mass in the Back: A Case Report and Review of Literature"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3504-2310","authenticated-orcid":false,"given":"Kai-Bo","family":"Chen","sequence":"first","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Equal contributors."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Equal contributors."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Li","family":"Jin","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Ping","family":"Xiang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"bibr1-10668969211005094","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9686"},{"key":"bibr2-10668969211005094","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2020.03.38"},{"key":"bibr3-10668969211005094","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.10.88"},{"key":"bibr4-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-7-84"},{"issue":"4","key":"bibr5-10668969211005094","first-page":"482","volume":"48","author":"Patel T","year":"2005","journal-title":"Indian J Pathol Microbiol."},{"key":"bibr6-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.2003.00410.x"},{"key":"bibr7-10668969211005094","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.10.125"},{"key":"bibr8-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000180"},{"key":"bibr9-10668969211005094","doi-asserted-by":"publisher","DOI":"10.21037\/jovs.2017.05.05"},{"key":"bibr10-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-011-0368-2"},{"key":"bibr11-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001023"},{"key":"bibr12-10668969211005094","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-2019-pps-10"},{"key":"bibr13-10668969211005094","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0124-RA"},{"key":"bibr14-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5652-y"},{"key":"bibr15-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3907"},{"key":"bibr16-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1080\/19338244.2020.1747966"},{"key":"bibr17-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.102949"},{"key":"bibr18-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1148\/rg.241035058"},{"key":"bibr19-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.16840"},{"key":"bibr20-10668969211005094","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.172.4.10587144"},{"key":"bibr21-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.3.713"},{"key":"bibr22-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivz303"},{"key":"bibr23-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13026"},{"key":"bibr24-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0063-2016"},{"key":"bibr25-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-016-0942-1"},{"key":"bibr26-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181e94121"},{"key":"bibr27-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930140310"},{"key":"bibr28-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650480019008"},{"key":"bibr29-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1992.tb01602.x"},{"key":"bibr30-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80732-6"},{"key":"bibr31-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1177\/106689699900700106"},{"key":"bibr32-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.09.130"},{"key":"bibr33-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.02.046"},{"key":"bibr34-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e31802e465c"},{"key":"bibr35-10668969211005094","first-page":"16","volume":"13","author":"Tertemiz KC","year":"2014","journal-title":"Respir Med Case Rep."},{"key":"bibr36-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3180ddc88f"},{"key":"bibr37-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.00110.x"},{"key":"bibr38-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02813.x"},{"key":"bibr39-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-015-9772-8"},{"key":"bibr40-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1007\/BF01054270"},{"key":"bibr41-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201404-165BC"},{"key":"bibr42-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-008-0071-3"},{"key":"bibr43-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1007\/s004200100240"},{"key":"bibr44-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"key":"bibr45-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20005.14.589"},{"key":"bibr46-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2019.04.010"},{"key":"bibr47-10668969211005094","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12788"},{"issue":"3","key":"bibr48-10668969211005094","first-page":"E132","volume":"20","author":"Scherpereel A","year":"2019","journal-title":"Lancet Oncol"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969211005094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969211005094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969211005094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:41Z","timestamp":1777458101000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969211005094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1177\/10668969211005094"],"URL":"https:\/\/doi.org\/10.1177\/10668969211005094","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,17]]}}}