{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:21:00Z","timestamp":1777717260761,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100019703","name":"Lunit Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019703","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Patterns of p53 immunostaining are used as a surrogate marker for tumor protein 53 ( TP53) mutations in the diagnosis of ovarian high-grade serous carcinoma (HGSC). We present a rare case of ovarian HGSC that metastasized to the diaphragm and cardiophrenic lymph nodes and showed the immunostaining pattern of wild-type p53 and aberrant neural cell adhesion molecule (CD56) expression. A 63-year-old woman developed multifocal metastases in the diaphragmatic pleura and cardiophrenic lymph nodes. Because she had a history of ovarian HGSC and pulmonary adenocarcinoma, we considered the possibility that the metastatic carcinoma was of either ovarian or pulmonary origin. Immunostaining revealed that the tumor cells were negative for thyroid transcription factor 1 but positive for Wilms tumor 1. The tumor additionally exhibited strong membranous CD56 expression and patchy p53 expression, both of which were inconsistent with the characteristics of ovarian HGSC. However, targeted sequencing analysis revealed that the tumor harbored a pathogenic mutation at the splice acceptor site of TP53 intron 9 (c.994-1G&gt;C).<\/jats:p>","DOI":"10.1177\/10668969211006194","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T02:03:35Z","timestamp":1616724215000},"page":"864-869","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiophrenic Lymph Node Metastasis of Ovarian High-grade Serous Carcinoma Showing Wild-type p53 Immunostaining Pattern and Aberrant CD56 Expression"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8800-7690","authenticated-orcid":false,"given":"Hee Jung","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea"},{"name":"Department of Pathology, Yeungnam University College of Medicine, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mijung","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea"},{"name":"Medical Research Center, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joungho","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"bibr1-10668969211006194","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2016.08.40"},{"key":"bibr2-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1159\/000475707"},{"key":"bibr3-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000207"},{"issue":"12","key":"bibr4-10668969211006194","first-page":"6697","volume":"37","author":"Na K","year":"2017","journal-title":"Anticancer Res"},{"key":"bibr5-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.766"},{"key":"bibr6-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.85"},{"key":"bibr7-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<814::AID-CNCR12>3.0.CO;2-U"},{"key":"bibr8-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001101)89:9<2006::AID-CNCR18>3.0.CO;2-7"},{"issue":"1","key":"bibr9-10668969211006194","first-page":"177","volume":"150","author":"Tashiro H","year":"1997","journal-title":"Am J Pathol."},{"key":"bibr10-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1038\/srep26191"},{"key":"bibr11-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000888"},{"key":"bibr12-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213422.53750.d1"},{"key":"bibr13-10668969211006194","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11628"},{"key":"bibr14-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23035"},{"key":"bibr15-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22552"},{"key":"bibr16-10668969211006194","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-016-0336-9"},{"key":"bibr17-10668969211006194","unstructured":"Carcangiu M, Kurman RJ, Carcangiu ML, Herrington CS. 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