{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:27:42Z","timestamp":1790314062648,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare and clinically aggressive RCC subtype that is commonly associated with the hereditary leiomyomatosis and renal cell carcinoma syndrome. The diagnostic hallmark of FH-deficient RCC is a high-grade microscopic appearance with prominent inclusion-like eosinophilic nucleoli and perinucleolar halos. Herein we report a case of an FH-deficient RCC in a 30-year-old female that exhibited low-grade nuclei and abundant eosinophilic cytoplasm, reminiscent of the clinically more indolent succinate dehydrogenase-deficient RCC subtype and the newly described eintity, eosinophilic, solid and cystic RCC. This case illustrates that FH-deficient RCC can have a wide spectrum of microscopic appearances, including low-grade eosinophilic RCC. In addition, it highlights that a low threshold to perform the immunohistochemical stains for FH and S-(2-succino) cysteine is warranted in RCC cases with unusual and even low-grade eosinophilic morphology.<\/jats:p>","DOI":"10.1177\/10668969211026241","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T11:17:12Z","timestamp":1624879032000},"page":"184-189","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Low-Grade Fumarate Hydratase-Deficient Renal Cell Carcinoma in a 30-Year-Old Female"],"prefix":"10.1177","volume":"30","author":[{"given":"Nicolas","family":"Wyvekens","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young X.","family":"Kim","sequence":"additional","affiliation":[{"name":"Kaiser Foundation Hospital, Southern California Permanente Medical Group, Baldwin Park, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Carter","sequence":"additional","affiliation":[{"name":"Kaiser Foundation Hospital, Southern California Permanente Medical Group, Baldwin Park, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-8564","authenticated-orcid":false,"given":"Michelle S.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"bibr1-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61757-9"},{"key":"bibr2-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051633798"},{"key":"bibr3-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001372"},{"key":"bibr4-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000573"},{"key":"bibr5-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63091-X"},{"key":"bibr6-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.222"},{"key":"bibr7-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1038\/nature19353"},{"key":"bibr8-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1002\/path.2932"},{"key":"bibr9-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000163"},{"key":"bibr10-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.07.004"},{"key":"bibr11-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000617"},{"key":"bibr12-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22878"},{"key":"bibr13-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318299f0fb"},{"key":"bibr14-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0017-7"},{"key":"bibr15-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31804375b8"},{"key":"bibr16-10668969211026241","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0464-RA"},{"key":"bibr17-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1111\/his.13183"},{"key":"bibr18-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1111\/his.13395"},{"key":"bibr19-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2019-205924"},{"key":"bibr20-10668969211026241","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0527-OA"},{"key":"bibr21-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1113"},{"key":"bibr22-10668969211026241","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2019.086"},{"key":"bibr23-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-019-0484-2"},{"key":"bibr24-10668969211026241","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00737-6"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969211026241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969211026241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969211026241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:48Z","timestamp":1777458108000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969211026241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,28]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/10668969211026241"],"URL":"https:\/\/doi.org\/10.1177\/10668969211026241","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,28]]}}}