{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:54:40Z","timestamp":1783418080646,"version":"3.54.6"},"reference-count":6,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is an emerging entity in renal neoplasia with distinctive histopathological findings and a generally favorable prognosis. The presence of melanin pigment in a renal tumor typically prompts the observer to consider the microphthalmia-associated transcription family translocation renal cell carcinomas. We present a renal tumor occurring in a 19-year-old male patient which had the typical morphology of ESC-RCC but showed the additional finding of focal melanin pigment. This tumor showed strong and diffuse positive immunolabeling with paired box gene 8 and cytokeratin 20, and was negative with epithelial membrane antigen, carbonic anhydrase 9, CD117, cytokeratin 7, and transcription factor E3. Human melanoma black-45 showed focal positivity, but Melan-A was negative. Next-generation sequencing revealed a mutation in the TSC2 gene (c.4490C\u2009&gt;\u2009G, p.[Pro1497Arg] and c.1257\u2009+\u20091del) and break apart fluorescence in-situ hybridization with TFE3 and TFEB probes was negative. In this case report, we present the novel finding of melanin pigment occurring in a genetically proven and otherwise typical ESC-RCC, and briefly discuss the differential diagnostic considerations.<\/jats:p>","DOI":"10.1177\/10668969211038737","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T06:54:58Z","timestamp":1629183298000},"page":"295-299","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Eosinophilic Solid and Cystic Renal Cell Carcinoma With Melanin Pigment\u2014Expanding the Morphological Spectrum"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-1692","authenticated-orcid":false,"given":"Alessandro Pietro","family":"Aldera","sequence":"first","affiliation":[{"name":"University of Cape Town, Cape Town, South Africa"},{"name":"JDW Pathology Incorporated, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Hes","sequence":"additional","affiliation":[{"name":"Charles University, Prague, Czech Republic"},{"name":"University Hospital, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"bibr1-10668969211038737","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000838"},{"key":"bibr2-10668969211038737","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001111"},{"key":"bibr3-10668969211038737","doi-asserted-by":"publisher","DOI":"10.1111\/his.13395"},{"key":"bibr4-10668969211038737","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31818fbdff"},{"key":"bibr5-10668969211038737","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000720"},{"key":"bibr6-10668969211038737","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.05.023"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969211038737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969211038737","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969211038737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:52Z","timestamp":1777458112000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969211038737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,17]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1177\/10668969211038737"],"URL":"https:\/\/doi.org\/10.1177\/10668969211038737","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,17]]}}}