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However, it is rarely encountered in hepatocellular carcinoma (HCC) in elderly adults, and the molecular mechanism of EMH in hepatic tumors remains unclear. We present a case of a 74-year-old man without any hematopoietic disorders and hepatitis viral infection who underwent hepatic resection for HCC. Histological examination revealed a well-differentiated HCC with trilineage hematopoiesis in the tumor and non-neoplastic liver. The coexistence of HCC and EMH in adult patients with no hematopoietic disorders is very rare and must be distinguished from poorly differentiated or dedifferentiated HCC and hepatoblastoma.<\/jats:p>","DOI":"10.1177\/10668969211050904","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T02:17:31Z","timestamp":1634696251000},"page":"339-345","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Adult Hepatocellular Carcinoma Coexisting with Extramedullary Hematopoiesis"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3738-9219","authenticated-orcid":false,"given":"Hirotsugu","family":"Noguchi","sequence":"first","affiliation":[{"name":"Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyo","family":"Higashi","sequence":"additional","affiliation":[{"name":"Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Desaki","sequence":"additional","affiliation":[{"name":"Tanegashima Medical Center, Kagoshima 891-3198, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tasaki","sequence":"additional","affiliation":[{"name":"Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kirishima","sequence":"additional","affiliation":[{"name":"Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4082-4050","authenticated-orcid":false,"given":"Ikumi","family":"Kitazono","sequence":"additional","affiliation":[{"name":"Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Tabata","sequence":"additional","affiliation":[{"name":"Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7508-1624","authenticated-orcid":false,"given":"Akihide","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"bibr1-10668969211050904","unstructured":"Stocker JT, Dehner LP, Husain AN (eds). 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