{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T14:00:57Z","timestamp":1782050457525,"version":"3.54.5"},"reference-count":27,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Histiocytic sarcoma is a rare, but aggressive malignant neoplasm of monocyte\/macrophage lineage with a wide age distribution. Bone involvement is exceedingly rarer compared to the lymph node, skin, and soft tissue, and no long bone involvement has been reported in the English literature. We here report 2 cases of histiocytic sarcoma involving the long bone: one from the femur of a 77-year-old female, status post the placement of an intramedullary nail for subtrochanteric hip fracture; the other from the radius of a 3-year-old female with no significant medical history. Radiologic imaging showed highly destructive lesions in both cases with soft-tissue extension. Microscopy in both cases showed sheets of polygonal mononuclear cells with abundant eosinophilic cytoplasm, prominent nucleoli, and frequent mitosis. Hemophagocytosis were also identified. Immunohistochemistry showed that the lesional cells were strongly diffusely positive for CD68 and CD163. The first patient deteriorated rapidly, despite the aggressive treatment of amputation and chemotherapy. However, the second patient is disease free 36 months post the treatment of amputation only. We conclude that the long bone could be the primary site of histiocytic sarcoma. Its prognosis could be very variable and it is difficult to predict its behavior based on morphological evaluation only.<\/jats:p>","DOI":"10.1177\/1066896921996464","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T12:08:08Z","timestamp":1616414888000},"page":"752-758","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Histiocytic Sarcoma Arising From a Long Bone: Report of Two Cases"],"prefix":"10.1177","volume":"29","author":[{"given":"Rana","family":"Ajabnoor","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center, Rochester, USA"},{"name":"Department of Pathology, Faculty of Medicine, King Abdulaziz University and King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoenix D.","family":"Bell","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Schiffman","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Carmody","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Monu","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8098-2064","authenticated-orcid":false,"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-10-812495"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1970.82"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01418.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-690636"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-124792"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.102"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI139682"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000131541.95394.23"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0704-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000649"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198163010-00010"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0026"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-011-1228-x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2012.0029"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20150393"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jons.2017.05.007"},{"key":"e_1_3_2_19_2","first-page":"1270","article-title":"Primary histiocytic sarcoma of bone with disseminated involvement\u2014initial presentation mimicking multiple myeloma: The atypical face of a rare neoplasm","volume":"6","author":"Lage LAPC","year":"2019","unstructured":"Lage LAPC, Albuquerque VJ, Moraes RDR, et al. 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