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When Castleman disease occurs in the retroperitoneum, the distinction from the inflammatory variant of well-differentiated liposarcoma can be very challenging in small biopsies. Herein we report a case of Castleman disease that presented as a retroperitoneal mass and expressed MDM2 and CDK4 by immunohistochemistry. To our knowledge, this is the first report of Castleman disease staining positively for MDM2\/CDK4, and it underscores how immunohistochemistry can potentially serve as a pitfall when differentiating this rare entity from retroperitoneal sarcomas.<\/jats:p>","DOI":"10.1177\/10668969221080083","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T08:16:27Z","timestamp":1644567387000},"page":"753-759","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Castleman Disease with MDM2\/CDK4 Protein Expression: a Potential Mimic of Inflammatory Variant of Liposarcoma with Significant Consequences"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-9075","authenticated-orcid":false,"given":"Natalia","family":"Georgantzoglou","sequence":"first","affiliation":[{"name":"Dartmouth Hitchcock Medical Center, Lebanon, NH, 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