{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:25:21Z","timestamp":1777717521425,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\u201cJuvenile-like (hyperplastic\/inflammatory) mucosal polyp\u201d is a term proposed for rare benign mesenchymal lesions of the gastro-intestinal tract so far reported only in patients with type 1 neurofibromatosis (NF1). We report here a first sporadic case of NF1-associated mucosal inflammatory polyp of the colon. The diagnosis was made in a 53-year old female patient with a large polypoid tumor of the cecum. The lesion was predominantly mucosal, made of fibroblast-like cells associated with inflammatory infiltrates rich in eosinophils and containing entrapped, distorted epithelial glands, responsible for the juvenile-like appearance. Whole exome sequencing showed a pathogenic variant of NF1. The patient had no evidence of NF1; no NF1 mutation was detected in normal tissues. Our observation may support the existence of juvenile-like inflammatory polyps associated with NF1 alterations, either germline or somatic. This justifies to test NF1 in difficult-to-classify gastrointestinal mesenchymal tumors.<\/jats:p>","DOI":"10.1177\/10668969221085819","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T06:00:04Z","timestamp":1646719204000},"page":"823-827","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>NF1<\/i>\n                    -Associated Inflammatory Polyp of the Colon: First Report of a Sporadic Case"],"prefix":"10.1177","volume":"30","author":[{"given":"Christina","family":"Kanaan","sequence":"first","affiliation":[{"name":"Gustave Roussy Cancer Campus, D\u00e9partement de Biologie et Pathologie M\u00e9dicales, Service de Pathologie morphologique, Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Cotteret","sequence":"additional","affiliation":[{"name":"Gustave Roussy Cancer Campus, D\u00e9partement de Biologie et 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