{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:11:47Z","timestamp":1790208707374,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR3047B"],"award-info":[{"award-number":["SHDC2020CR3047B"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Province","doi-asserted-by":"publisher","award":["2018D01C027"],"award-info":[{"award-number":["2018D01C027"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Foundation of ShangHai Pulmonary Hospital","award":["FK1937"],"award-info":[{"award-number":["FK1937"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Visceral pleural invasion (VPI) is a critical component in the staging of peripheral non-small cell lung carcinoma (NSCLC). We aim to investigate whether dual-block elastic stain increases visceral pleural invasion positivity compared with single-block elastic stain. We further analyze the potential predictors of visceral pleural invasion. 8419 peripheral NSCLC patients (including 6008 patients with tumor size\u22643\u2005cm in stage I) were divided into a cohort using one paraffin block (single-block group, n\u2009=\u20095184) and a cohort using dual paraffin blocks (dual-block group, n\u2009=\u20093235) for elastic stain. The VPI-positive rate demonstrated by the dual-block elastic stains group was significantly higher than that of the single-block elastic stain group (17.7% (573\/3235) versus 9.1% (474\/5184), respectively, P\u2005&lt;\u2005.001). The presence of visceral pleural invasion in T1 (\u22643\u2005cm) patients detected by single- and dual-block elastic stain was 6.3% (235\/3730) and 12.0% (273\/2278), respectively ( P\u2005&lt;\u2005.001). 5.7% of T1 patients (stage IA) were additionally upstaged to T2a (stage IB) by dual-block elastic stain. However, the incidence of visceral pleural invasion in pT2a patients showed no significant difference between the single-block group and the dual-block group (16.8% vs. 17.1%, P\u2009=\u2009.916). Lymphovascular invasion, lymph node metastasis, dedifferentiated carcinomas, the presence of spread through airspaces (STAS) and a poorly differentiated adenocarcinomatous growth pattern could be significant predictors of visceral pleural invasion ( P\u2005&lt;\u2005.001). Our results indicate that using dual-block elastic stain identifies more visceral pleural invasion positive T1 NSCLC patients who are upstaged to T2a, and who could benefit from optimal management post-operatively. The application of dual-block elastic stain is an efficient and practical method to detect visceral pleural invasion status.<\/jats:p>","DOI":"10.1177\/10668969221098089","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T07:49:22Z","timestamp":1656316162000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Significance of Dual-Block Elastic Stain Evaluating Visceral Pleural Invasion in Peripheral Non-Small Cell Lung Cancer"],"prefix":"10.1177","volume":"31","author":[{"given":"Shaoling","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanghai Pulmonary Hospital, School 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Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-8342","authenticated-orcid":false,"given":"Likun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"bibr1-10668969221098089","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"bibr2-10668969221098089","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.02.009"},{"key":"bibr3-10668969221098089","volume-title":"Pulmonary 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