{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:26:15Z","timestamp":1777717575851,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Malignant peripheral nerve sheath tumor (MPNST) is a spindle cell sarcoma originating from peripheral nerves or showing differentiation of nerve sheath components. Primary MPNST of the stomach is an extremely rare neoplasm with only a few published reports in the literature. We present the case of a 58-year-old male patient with MPNST in the stomach. The patient was admitted due to upper abdomen discomfort. Gastroscopy revealed a huge ulcer lesion in the stomach, and biopsy revealed a spindle cell malignant neoplasm. No other specific findings were found in the whole-body imaging examination. Subtotal gastrectomy was performed. Histologically, an ulcer-type, push-infiltrating mass composed of dense, woven-like spindle cells with frequent mitosis could be seen. In immunohistochemistry, the tumor cells were negative for expression of H3K27 trimethylation (H3K27me3), keratin (AE1\/AE3), epithelial membrane antigen (EMA), CD34, KIT, DOG1 ( ANO1), S-100, SOX10, smooth muscle actin, desmin, myogenin, MDM2, CDK4, P16 ( CDKN2A) and SS18-SSX ( SS18::SSX). Primary MPNST of the stomach was diagnosed based on histological and immunohistochemical results. During the 2.5\u2009years follow-up period after surgery, no recurrence was observed.<\/jats:p>","DOI":"10.1177\/10668969221098094","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T03:17:18Z","timestamp":1651461438000},"page":"221-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Primary Malignant Peripheral Nerve Sheath Tumor of the Stomach: A Rare Case Report and Review of Literature"],"prefix":"10.1177","volume":"31","author":[{"given":"Wenwen","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Pathology, Binzhou People\u2019s Hospital, Binzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihang","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Thyroid surgery, Binzhou People\u2019s Hospital, Binzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Binzhou People\u2019s Hospital, Binzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Binzhou People\u2019s Hospital, Binzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1449-2280","authenticated-orcid":false,"given":"Xinjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Binzhou People\u2019s Hospital, Binzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"bibr1-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6"},{"key":"bibr2-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22098"},{"key":"bibr3-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1978-7"},{"key":"bibr4-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1979.tb02983.x"},{"issue":"3","key":"bibr5-10668969221098094","first-page":"221","volume":"99","author":"Radulescu D","year":"1995","journal-title":"Rev Med Chir Soc Med Nat Iasi."},{"key":"bibr6-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.70.837.9486074"},{"key":"bibr7-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199802000-00012"},{"key":"bibr8-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-6-37"},{"key":"bibr9-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181658c14"},{"key":"bibr10-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx060"},{"key":"bibr11-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000564"},{"key":"bibr12-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.97"},{"key":"bibr13-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.91"},{"key":"bibr14-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1540-6"},{"key":"bibr15-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001447"},{"issue":"5","key":"bibr16-10668969221098094","first-page":"1573","volume":"62","author":"Ferner RE","year":"2002","journal-title":"Cancer Res."},{"key":"bibr17-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-4-55"},{"key":"bibr18-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870101)59:1"},{"key":"bibr19-10668969221098094","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00324"},{"key":"bibr20-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00223-5"},{"key":"bibr21-10668969221098094","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq338"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221098094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969221098094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221098094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:22:35Z","timestamp":1777458155000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969221098094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1177\/10668969221098094"],"URL":"https:\/\/doi.org\/10.1177\/10668969221098094","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,2]]}}}