{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:44:53Z","timestamp":1790595893589,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Introduction<\/jats:italic>\n                    . Epithelioid hemangioma is a benign vascular neoplasm associated with FOS and\/or FOSB protein overexpression detected by immunohistochemistry (IHC).\n                    <jats:italic toggle=\"yes\">Methods<\/jats:italic>\n                    . The aim of our study was to determine the co-expression or independent IHC expression of FOS and FOSB in a cohort of epithelioid hemangiomas. We also included two cohorts of other vascular lesions: papillary endothelial hyperplasia and lobular capillary hemangioma \/ pyogenic granuloma.\n                    <jats:italic toggle=\"yes\">Results<\/jats:italic>\n                    . We identified 50 cases of epithelioid hemangioma, 84% of which were cutaneous and the remaining involved other anatomic locations. Over two thirds of all cases expressed FOSB (68%; 34\/50) while FOS immunoreactivity was identified in 46% of all cases. Co-expression of FOSB and FOS occurred in 37% of cases while 76% of all cases stained for at least one of the antibodies. Fifty-eight percent (n\u2009=\u200914\/24) and 33% (8\/24) of all cases of papillary endothelial hyperplasia expressed FOS and FOSB, respectively. Thirty-two per cent of lobular capillary hemangiomas (n\u2009=\u20098\/25) were positive for either FOS or FOSB.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    . In summary, we present the largest cohort of epithelioid hemangiomas assessed with both FOS and FOSB and demonstrated that the use of both antibodies increases the detection rate of these proliferations by 10%. Nonetheless, the use of thresholds may not be appropriate, as only a subset of lesional endothelial cells label with FOS\/FOSB. Over half of all cases of papillary endothelial hyperplasia and a third of lobular capillary hemangiomas also displayed immunoreactivity with FOS and\/or FOSB.\n                  <\/jats:p>","DOI":"10.1177\/10668969221101867","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T02:23:52Z","timestamp":1653877432000},"page":"280-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Immunohistochemistry for FOSB and FOS is a Useful Ancillary Tool in the Diagnosis of Epithelioid Hemangioma but There are Pitfalls in Interpretation Including Expression in Other Vascular Lesions"],"prefix":"10.1177","volume":"31","author":[{"given":"Kwan Yee","family":"Tsui","sequence":"first","affiliation":[{"name":"Douglass Hanly Moir Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Maclean","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology"},{"name":"Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia"},{"name":"Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Moir","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Cheah","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Bonar","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Tabot","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Gill","sequence":"additional","affiliation":[{"name":"Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia"},{"name":"University of Sydney, Sydney, Australia"},{"name":"NSW Health Pathology, Department of Anatomical Patohlogy, Royal North Shore Hospital, St Leonards, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3798-5088","authenticated-orcid":false,"given":"A. Cristina","family":"Vargas","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology"},{"name":"Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia"},{"name":"University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13141"},{"key":"e_1_3_3_3_2","volume-title":"WHO Classification of Skin Tumours 4th Edition, volume 11, 2018","author":"Elder DE","unstructured":"Elder DE, Massi D, Scolyer RA, Willemze R. WHO Classification of Skin Tumours 4th Edition, volume 11, 2018. International Agency for Research on Cancer; 2018."},{"key":"e_1_3_3_4_2","first-page":"449","article-title":"Observations concerning the pathogenesis of epithelioid hemangioma (angiolymphoid hyperplasia)","author":"Fetsch JF","unstructured":"Fetsch JF, Weiss SW. Observations concerning the pathogenesis of epithelioid hemangioma (angiolymphoid hyperplasia). 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The transcription factor fos: a Janus-type regulator in health and disease. 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