{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:20:13Z","timestamp":1790266813675,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>\n                    Ameloblastic carcinoma is a rare malignant neoplasm arising from the odontogenic epithelium. Ameloblastic carcinoma commonly occurs de novo affecting the posterior segments of the mandible. Presently, only less than 100 cases have been reported arising from the maxilla. We report a unique case of maxillary ameloblastic carcinoma in a 68-year-old male with a 5.6\u2005cm positron emission tomography (PET) avid left maxillary sinus mass. The patient underwent a left maxillectomy which revealed hyperchromatic and pleomorphic tumor cells arranged in a nested and trabecular architecture. The tumor cells showed distinct peripheral palisading with reverse polarization. Areas of bone destruction, necrosis, lymphovascular and perineural invasions, as well as atypical mitoses, were identified. Immunohistochemically, the tumor cells were positive for keratin cocktail (AE1\/AE3 and CAM 5.2), keratin 19, p40, and weakly positive for MDM2, while negative for calretinin. Molecular analysis revealed wild-type\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    ; however, alterations in\n                    <jats:italic toggle=\"yes\">CDKN2A<\/jats:italic>\n                    \/\n                    <jats:italic toggle=\"yes\">B<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">MTAP<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">RB1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">SMARCA4<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">STK11<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">FGF12<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">SETD2<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    were present. This histopathologic and molecular profile supported the diagnosis of ameloblastic carcinoma. There has been no evidence of disease recurrence or metastasis eleven months after the initial diagnosis.\n                  <\/jats:p>","DOI":"10.1177\/10668969221102542","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T01:23:26Z","timestamp":1654565006000},"page":"442-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Ameloblastic Carcinoma of the Maxilla: A Rare Case Report and Review of Literature from 1948 to 2021"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-2111","authenticated-orcid":false,"given":"Irene Y.","family":"Chen","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen J.","family":"Giampoli","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Indiana University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25926"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90099-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.05.026"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90207-x"},{"key":"e_1_3_2_6_2","volume-title":"World Health Organization Classification of tumours: Pathology and genetics of tumours of the head and neck","author":"Barnes L","year":"2005","unstructured":"Barnes L, Eveson JW, Reichart P, et al. World Health Organization Classification of tumours: Pathology and genetics of tumours of the head and neck. IARC Press; 2005."},{"key":"e_1_3_2_7_2","volume-title":"Head and neck tumours [Internet; beta version ahead of print]","author":"WHO Classification of Tumours Editorial Board","year":"2022","unstructured":"WHO Classification of Tumours Editorial Board. Head and neck tumours [Internet; beta version ahead of print]. International Agency for Research on Cancer; 2022, (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"e_1_3_2_8_2","volume-title":"World Health Organization Classification of Head and Neck Tumours","author":"El-Naggar AK","year":"2017","unstructured":"El-Naggar AK, Chan JK, Grandis JR. World Health Organization Classification of Head and Neck Tumours. 4th ed. International Agency for Research on Cancer; 2017.","edition":"4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5272"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2654"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-1-31"},{"issue":"4","key":"e_1_3_2_12_2","first-page":"1515","article-title":"Ameloblastic carcinoma, primary type: case report, immunohistochemical analysis and literature review","volume":"32","author":"Casaroto AR","year":"2012","unstructured":"Casaroto AR, Toledo GL, Filho JL, Soares CT, Capelari MM, Lara VS. Ameloblastic carcinoma, primary type: case report, immunohistochemical analysis and literature review. Anticancer Res. 2012;32(4):1515\u20101525.","journal-title":"Anticancer Res"},{"key":"e_1_3_2_13_2","volume-title":"Head and neck tumours [Internet; beta version ahead of print]","author":"Odell E","year":"2022","unstructured":"Odell E, Muller S, Richardson MS. Ameloblastic carcinoma. In: WHO Classification of Tumours Editorial Board, ed. Head and neck tumours [Internet; beta version ahead of print]. International Agency for Research on Cancer; 2022. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"e_1_3_2_14_2","volume-title":"Head and neck tumours [Internet; beta version ahead of print]","author":"Rooper LM","year":"2022","unstructured":"Rooper LM, Bishop J, Flucke U, Weinreb I. Ewing sarcoma. In: WHO Classification of Tumours Editorial Board, ed. Head and neck tumours [Internet; beta version ahead of print]. International Agency for Research on Cancer; 2022. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"e_1_3_2_15_2","volume-title":"Head and neck tumours [Internet; beta version ahead of print]","author":"Jain D","year":"2022","unstructured":"Agaimy A, Din NU, Jain D, Rooper LM, Bal M, Mittal N. SWI\/SNF complex-deficient sinonasal carcinoma (SMARCB1 & SMARCA4). In: WHO Classification of Tumours Editorial Board, ed. Head and neck tumours [Internet; beta version ahead of print]. International Agency for Research on Cancer; 2022. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"e_1_3_2_16_2","volume-title":"Head and neck tumours [Internet; beta version ahead of print]","author":"Minato H","year":"2022","unstructured":"French CA, Stelow EB, Minato H. NUT Carcinoma. In: WHO Classification of Tumours Editorial Board, ed. Head and neck tumours [Internet; beta version ahead of print]. International Agency for Research on Cancer; 2022. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"e_1_3_2_17_2","volume-title":"Head and neck tumours [Internet; beta version ahead of print]","author":"Bishop JA","year":"2022","unstructured":"Bishop JA, , Wenig BM. Basaloid squamous cell carcinoma. In: WHO Classification of Tumours Editorial Board, ed. Head and neck tumours [Internet; beta version ahead of print]. International Agency for Research on Cancer; 2022. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"e_1_3_2_18_2","volume-title":"Head and neck tumours [Internet; beta version ahead of print]","author":"Neville BW","year":"2022","unstructured":"Bilodeau EA, Maiorano E, Neville BW. Clear cell odontogenic carcinoma. In: WHO Classification of Tumours Editorial Board, ed. Head and neck tumours [Internet; beta version ahead of print]. International Agency for Research on Cancer; 2022. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31828a6727"},{"key":"e_1_3_2_20_2","volume-title":"Head and neck tumours [Internet; beta version ahead of print]","author":"Koutlas IG,","year":"2022","unstructured":"Koutlas IG, , Sloan P. Primary intraosseous carcinoma, NOS. In: WHO Classification of Tumours Editorial Board, ed. Head and neck tumours [Internet; beta version ahead of print]. International Agency for Research on Cancer; 2022. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"e_1_3_2_21_2","volume-title":"Head and neck tumours [Internet; beta version ahead of print]","author":"Jo VY, Agaimy A","year":"2022","unstructured":"Jo VY, Agaimy A, Din NU, Franchi A. Sinonasal undifferentiated carcinoma. In: WHO Classification of Tumours Editorial Board, ed. Head and neck tumours [Internet; beta version ahead of print]. International Agency for Research on Cancer; 2022. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.07.010"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3238-0"},{"issue":"1","key":"e_1_3_2_24_2","first-page":"31","article-title":"Spindle-cell ameloblastic carcinoma: a case report with immunohistochemical, ultrastructural, and comparative genomic hybridization analyses","volume":"10","author":"Kawauchi S","year":"2003","unstructured":"Kawauchi S, Hayatsu Y, Takahashi M, et al. Spindle-cell ameloblastic carcinoma: a case report with immunohistochemical, ultrastructural, and comparative genomic hybridization analyses. Oncol Rep. 2003;10(1):31\u201034.","journal-title":"Oncol Rep"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.04.033"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.03.021"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2323-3"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.168856"},{"issue":"6","key":"e_1_3_2_29_2","first-page":"1016","article-title":"Massive skull base ameloblastic carcinoma with intracranial extension","volume":"27","author":"Y\u0131ld\u0131r\u0131m AE","year":"2017","unstructured":"Y\u0131ld\u0131r\u0131m AE, Divanl\u0131o\u011flu D, Karao\u011flu D, et al. Massive skull base ameloblastic carcinoma with intracranial extension. Turk Neurosurg. 2017;27(6):1016\u20101020.","journal-title":"Turk Neurosurg."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.09.028"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2016.42.1.43"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2018.79544"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.08.014"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6265"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.01.071"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.09.009"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_116_17"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2020.2104"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2020.61.271"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_71_20"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.775136"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-5196"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221102542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969221102542","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221102542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:57:00Z","timestamp":1787759820000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969221102542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,6]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1177\/10668969221102542"],"URL":"https:\/\/doi.org\/10.1177\/10668969221102542","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,6]]}}}