{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:26:02Z","timestamp":1787761562817,"version":"build-2784847793"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    MiT family translocation renal cell carcinomas harbor gene fusion involving members of MiT family of transcription factors. Their precursor lesions have not been identified. Herein, we report the first case of small papillary tumors morphologically resembling papillary adenomas but harboring\n                    <jats:italic toggle=\"yes\">TFE3<\/jats:italic>\n                    gene alteration. The patient was a 23-year old man with multiple small papillary tumors in the right kidney discovered following a gunshot wound injury. These lesions were &lt; 5\u2005mm, well-circumscribed but not encapsulated tubulopapillary proliferation lined with a single layer of cuboidal cells with WHO\/ISUP grade 1 or 2 nuclei. The tumor cells were immunoreactive to PAX8, AMACR, high molecular weight cytokeratin, and keratin 7 and negative for CD10, CA9, TTF1, and cathepsin K. Morphologically and immunohistochemically, these lesions were diagnosed as papillary adenomas.\n                    <jats:italic toggle=\"yes\">TFE3<\/jats:italic>\n                    gene rearrangement was confirmed by fluorescence in-situ hybridization (FISH) using a\n                    <jats:italic toggle=\"yes\">TFE3<\/jats:italic>\n                    break-apart probe. We term these tumors \u201cpapillary adenoma-like\u201d renal tumor with TFE3 gene rearrangement. These tumors are likely a precursor to or represent an early event in the development of\n                    <jats:italic toggle=\"yes\">TFE3<\/jats:italic>\n                    translocation renal cell carcinomas. An understanding of such tumors to translocation renal cell carcinoma progression can provide insight into the pathogenic mechanism, and ultimately aid the diagnosis and management of translocation renal cell carcinoma.\n                  <\/jats:p>","DOI":"10.1177\/10668969221108747","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:52:11Z","timestamp":1658191931000},"page":"592-595","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["\u201cPapillary Adenoma-like\u201d Renal Tumor with\n                    <i>TFE3<\/i>\n                    Gene Rearrangement, A Potential Precursor to or Early Event in the Development of TFE3 Translocation Renal Cell Carcinoma"],"prefix":"10.1177","volume":"31","author":[{"given":"Khalid","family":"Algarrahi","sequence":"first","affiliation":[{"name":"Tufts Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evanthia","family":"Omoscharka","sequence":"additional","affiliation":[{"name":"University of Missouri-Kansas City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-7178","authenticated-orcid":false,"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tufts Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.02.029"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001189"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000090924.90762.94"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.07.016"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01018-6."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.02.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2020-206899"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181dd577e"},{"key":"e_1_3_2_10_2","unstructured":"American Cancer Society. Cancer Facts & Figures 2022. Last accessed March 1 2022. https:\/\/www.cancer.org\/content\/dam\/cancer-org\/research\/cancer-facts-and-statistics\/annual-cancer-facts-and-figures\/2022\/2022-cancer-facts-and-figures.pdf."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896909354337"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1309\/LR5G1VMXPY3G0CUK"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cancerbio-030518-055835"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1183"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.784993"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221108747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969221108747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221108747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:59:39Z","timestamp":1787759979000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969221108747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1177\/10668969221108747"],"URL":"https:\/\/doi.org\/10.1177\/10668969221108747","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]}}}