{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:06:02Z","timestamp":1793023562564,"version":"4.5.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,10,16]],"date-time":"2022-10-16T00:00:00Z","timestamp":1665878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Introduction.<\/jats:italic>\n                    Chromophobe renal cell carcinoma (chromophobe RCC) is the third major subcategory of renal tumors after clear cell RCC and papillary RCC, accounting for approximately 5% of all RCC subtypes. Other oncocytic neoplasms seen commonly in surgical pathology practice include the eosinophilic variant of chromophobe RCC, renal oncocytoma, and low-grade oncocytic unclassified RCC.\n                    <jats:italic toggle=\"yes\">Methods.<\/jats:italic>\n                    In our recent next-generation sequencing based study, we nominated a lineage-specific novel biomarker\n                    <jats:italic toggle=\"yes\">LINC01187<\/jats:italic>\n                    (long intergenic non-protein coding RNA 1187) which was found to be enriched in chromophobe RCC. Like KIT (cluster of differentiation 117; CD117), a clinically utilized chromophobe RCC related biomarker,\n                    <jats:italic toggle=\"yes\">LINC01187<\/jats:italic>\n                    is expressed in intercalated cells of the nephron. In this follow-up study, we performed KIT immunohistochemistry and\n                    <jats:italic toggle=\"yes\">LINC01187<\/jats:italic>\n                    RNA in situ hybridization (RNA-ISH) on a cohort of chromophobe RCC and other renal neoplasms, characterized the expression patterns, and quantified the expression signals of the two biomarkers in both primary and metastatic settings.\n                    <jats:italic toggle=\"yes\">Results.<\/jats:italic>\n                    <jats:italic toggle=\"yes\">LINC01187<\/jats:italic>\n                    , in comparison to KIT, exhibits stronger and more uniform expression within tumors while maintaining temporal and spatial consistency.\n                    <jats:italic toggle=\"yes\">LINC01187<\/jats:italic>\n                    also is devoid of intra-tumoral heterogeneous expression pattern, a phenomenon commonly noted with KIT.\n                    <jats:italic toggle=\"yes\">Conclusions.<\/jats:italic>\n                    <jats:italic toggle=\"yes\">LINC01187<\/jats:italic>\n                    expression can augment the currently utilized KIT assay and help facilitate easy microscopic analyses in routine surgical pathology practice.\n                  <\/jats:p>","DOI":"10.1177\/10668969221125793","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T02:43:01Z","timestamp":1665974581000},"page":"1027-1040","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Characterization of Intercalated Cell Markers KIT and\n                    <i>LINC01187<\/i>\n                    in Chromophobe Renal Cell Carcinoma and Other Renal Neoplasms"],"prefix":"10.1177","volume":"31","author":[{"given":"Rahul","family":"Mannan","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpinder S.","family":"Bawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5631-5381","authenticated-orcid":false,"given":"Stephanie L.","family":"Skala","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya K.","family":"Chinnaiyan","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniket","family":"Dagar","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Wang","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia B.","family":"Zelenka-Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"McMurry","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Daniel","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"},{"name":"Michigan Center for Translational 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