{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:18:44Z","timestamp":1787811524213,"version":"build-2784847793"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Introduction.<\/jats:italic>\n                    Five cases of non-small cell lung carcinoma (NSCLC) with diffuse coexpression of TTF1 and p40 in the same tumor cells (hereafter referred to as TTF1\/P40-NSCLC) have been reported since 2015. It was considered a new entity of NSCLC occurred in aged male smokers with poorly differentiated carcinomas and a similar molecular signature harboring a\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    mutation.\n                    <jats:italic toggle=\"yes\">Methods.<\/jats:italic>\n                    We report an extremely rare tumor of TTF1\/P40-NSCLC. Morphological observation and immunohistochemical examination were performed, clinical and molecular features were summarized, and a review of the relevant literature was provided.\n                    <jats:italic toggle=\"yes\">Results.<\/jats:italic>\n                    The tumor showed a solid growth pattern with patchy necrosis, and glandular and squamous pattern were not obvious. The tumor cells proliferated within the bronchial epithelium. Spreading through air spaces of tumor cells were observed. A peculiar immunohistochemical phenotype of diffuse and strong positivity for TTF1 (8G7G3\/1) and p40 in the same tumor cells was detected. Additionally, the tumor cells were positive for KRT7 and KRT20, while negative for PD-L1 (22C3). Negative P53 (null) Immunohistochemistry (IHC) staining indicated mutational status and the Ki67 index was 80%. Molecular investigation was performed using whole exome sequencing, and\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">NOTCH2<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">STK11<\/jats:italic>\n                    mutations were detected. The patient remained alive over a follow-up period of 22 months without tumor recurrence or metastasis.\n                    <jats:italic toggle=\"yes\">Conclusions.<\/jats:italic>\n                    We describe an unusual tumor of TTF1\/P40-NSCLC harboring\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">NOTCH2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">STK11<\/jats:italic>\n                    mutations. These gene mutations may be helpful in providing additional therapeutic possibilities. Our report offers further insight into this rare tumor.\n                  <\/jats:p>","DOI":"10.1177\/10668969221126105","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T23:15:22Z","timestamp":1666048522000},"page":"1041-1047","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["TP53, NOTCH2, and STK11 Mutations in a Rare Tumor of non-Small Cell Lung Carcinoma with Diffuse Coexpression of TTF1 and p40 in the Same Tumor Cells"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4517-9676","authenticated-orcid":false,"given":"Xingmei","family":"Guo","sequence":"first","affiliation":[{"name":"The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Dong","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengan","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"WHO Classification of Tumours: Thoracic Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2021","unstructured":"WHO Classification of Tumours Editorial Board. WHO Classification of Tumours: Thoracic Tumours. 5th ed. International Agency for Research on Cancer; 2021.","edition":"5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.173"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10010025"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31823815d3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000553"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.01.023"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-12-19"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2021.100222"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.12.005"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1221_15"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(88)80201-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001127"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/583929"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12855"},{"issue":"2","key":"e_1_3_3_16_2","first-page":"279","article-title":"Precision medicine for human cancers with Notch signaling dysregulation (review)","volume":"45","author":"Katoh M","year":"2020","unstructured":"Katoh M, Katoh M. Precision medicine for human cancers with Notch signaling dysregulation (review). Int J Mol Med. 2020;45(2):279-297.","journal-title":"Int J Mol Med"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0099"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.03.114"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221126105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969221126105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221126105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:39:14Z","timestamp":1787809154000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969221126105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1177\/10668969221126105"],"URL":"https:\/\/doi.org\/10.1177\/10668969221126105","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,17]]}}}