{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:25:21Z","timestamp":1787761521828,"version":"build-2784847793"},"reference-count":62,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    We report the histopathological, immunohistochemical (IHC), and molecular findings in 3 patients with adult pancreatoblastoma, including 2 with autopsy features. The tumors were located in the tail and body of the pancreas, and the 2 autopsy examinations revealed liver and lung metastases. Histopathologically the neoplasms were composed of solid epithelial elements with nested or trabecular growth patterns, fibrous stroma, and squamoid clusters. Keratin 19 was positive mainly in squamoid corpuscles, and trypsin or chymotrypsin was positive in the acinar component. Neuroendocrine differentiation was observed in all tumors, and nuclear \u03b2-catenin expression in 2 tumors. Despite nuclear \u03b2-catenin expression,\n                    <jats:italic toggle=\"yes\">CTNNB1<\/jats:italic>\n                    mutation was found only in tumor 2.\n                    <jats:italic toggle=\"yes\">APC<\/jats:italic>\n                    mutation was detected in tumor 1, and\n                    <jats:italic toggle=\"yes\">SMAD4<\/jats:italic>\n                    as well as\n                    <jats:italic toggle=\"yes\">MEN1<\/jats:italic>\n                    mutations in tumor 3. This last tumor also revealed chromosomal instability with many chromosomal losses and gains. The follow-up showed regional or distant metastases in all patients. Two patients died of disease after 3 and 26 months of follow-up and 1 patient is alive with no evidence of disease 6 years and 2 months after surgery. Adult pancreatoblastoma can display genetic heterogeneity, diverse histological appearance, and overlapping IHC findings. As a result, the differential diagnosis with other adult pancreatic tumors, such as acinar cell carcinoma, neuroendocrine neoplasm, solid pseudopapillary neoplasm, and mixed tumors may be challenging, especially when dealing with limited tumor tissue. The identification of squamoid corpuscles is essential for diagnosis. Although molecular findings might provide useful information, the integration of clinical, radiological, and histopathological findings is essential in pancreatoblastoma diagnosis.\n                  <\/jats:p>","DOI":"10.1177\/10668969221133351","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T01:25:01Z","timestamp":1672104301000},"page":"896-906","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Adult Pancreatoblastoma: Report of 3 new Cases With Genetic Diversity and Autopsy Findings"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-1330","authenticated-orcid":false,"given":"Isidro","family":"Machado","sequence":"first","affiliation":[{"name":"Department of Pathology, Instituto Valenciano de Oncolog\u00eda, Valencia, Spain"},{"name":"Patologika Laboratory, Hospital Quir\u00f3nSalud, Valencia, Spain"},{"name":"University of Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"L\u00f3pez-Guerrero","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Instituto Valenciano de Oncolog\u00eda, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fernandez","sequence":"additional","affiliation":[{"name":"University of Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Instituto Valenciano de Oncolog\u00eda, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Garc\u00eda Casado","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Instituto Valenciano de Oncolog\u00eda, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ferrandez","sequence":"additional","affiliation":[{"name":"University of Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Llombart-Bosch","sequence":"additional","affiliation":[{"name":"University of Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-2704","authenticated-orcid":false,"given":"Gregory W.","family":"Charville","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"issue":"7","key":"e_1_3_2_2_2","first-page":"650","article-title":"Pancreatoblastoma in an adult","volume":"110","author":"Palosaari D","year":"1986","unstructured":"Palosaari D, Clayton F, Seaman J. 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