{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:25:10Z","timestamp":1787761510731,"version":"build-2784847793"},"reference-count":13,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background.<\/jats:italic>\n                    Micronodular thymic carcinoma (MTC) with lymphoid hyperplasia is believed to be the malignant counterpart of micronodular thymoma (MT) with lymphoid hyperplasia. Since MT and MTC share a similar morphology, MTC is considered a malignant form of MT; there have been a few malignant transformations from MT to MTC. We report a case of MTC with lymphoid hyperplasia.\n                    <jats:italic toggle=\"yes\">Case presentation.<\/jats:italic>\n                    A 53-year-old woman presented with an incidental tumor on a chest X-ray. The resected tumor consisted of nodular epithelial nests and lymphoid tissue within a surrounding germinal center. Some epithelial nests showed apparent malignant morphology. Atypical epithelial cells with large vesicular nuclei formed nests, some of which showed comedo necrosis. These cells showed transition continuously to low-grade type B thymoma-like cells, demonstrating cord-like arrangements. Carcinomatous elements, expressed GLUT1, CD5, KIT, and BCL2; conversely, low-grade nests displayed attenuated expression of these markers.\n                    <jats:italic toggle=\"yes\">GTF2I<\/jats:italic>\n                    point mutation and Langerhans\/dendritic cells, which are indicators of favorable thymoma prognosis, were not detected. Due to pleural metastasis, the patient was treated with lenvatinib 27 months postoperatively.\n                    <jats:italic toggle=\"yes\">Conclusions.<\/jats:italic>\n                    This is the first report of a partially low-grade,\n                    <jats:italic toggle=\"yes\">GTF2I<\/jats:italic>\n                    -negative MTC. Histological and genetic findings might be predictive of tumor prognosis.\n                  <\/jats:p>","DOI":"10.1177\/10668969221133357","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T02:30:58Z","timestamp":1667183458000},"page":"785-790","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Micronodular Thymic Carcinoma with Lymphoid Stroma: A Case Report"],"prefix":"10.1177","volume":"31","author":[{"given":"Koki","family":"Zaitsu","sequence":"first","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-8002","authenticated-orcid":false,"given":"Haruto","family":"Nishida","sequence":"additional","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Kondo","sequence":"additional","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kusaba","sequence":"additional","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Oyama","sequence":"additional","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Daa","sequence":"additional","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,30]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"345","volume-title":"WHO Classification of tumours editorial board WHO classification of tumours. Thoracic tumours","author":"Tateyama H","year":"2021","unstructured":"Tateyama H, Girard N, Roden AC, Str\u00f6bel P Micronodular thymoma with lymphoid stroma: In: WHO Classification of tumours editorial board WHO classification of tumours. Thoracic tumours. IARC. 2021: 345-346."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199908000-00014"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01133.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.40"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.104"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i23.4063"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13099"},{"key":"e_1_3_3_9_2","article-title":"Comparative clinicopathological and immunohistochemical study of micronodular thymoma and micronodular thymic carcinoma with lymphoid stroma","author":"Liu PP","year":"2021","unstructured":"Liu PP, Su YC, Niu Y, Shi YF, Luo J, Zhong DR. Comparative clinicopathological and immunohistochemical study of micronodular thymoma and micronodular thymic carcinoma with lymphoid stroma. J Clin Pathol. 2021;75(10):702-705.","journal-title":"J Clin Pathol"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03044-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3016"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.10.001"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.105"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12428"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221133357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969221133357","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221133357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:59:40Z","timestamp":1787759980000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969221133357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,30]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1177\/10668969221133357"],"URL":"https:\/\/doi.org\/10.1177\/10668969221133357","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,30]]}}}