{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:26:34Z","timestamp":1787761594948,"version":"build-2784847793"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    Atypical ductal hyperplasia and low-grade ductal carcinoma\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    (DCIS) are regarded as precursor lesions of estrogen receptor (ER)-positive invasive breast cancer. In\n                    <jats:italic toggle=\"yes\">HER2<\/jats:italic>\n                    -amplified invasive breast cancer, a precursor lesion before DCIS has not yet been described. Here we introduce a case of HER2-positive lobules in the breast without histological abnormality. A 39-year-old premenopausal woman visited a hospital due to identification of microcalcifications on screening mammography. The subsequent biopsy confirmed high-grade DCIS. She underwent wide excision, and a residual high-grade DCIS with a size of 1.4\u2005cm was found. The tumor cells were hormone receptor positive and HER2 negative on immunohistochemical (IHC) staining. Around DCIS, there were terminal duct lobular units (TDLUs) showing strong HER2 positivity on IHC. These HER2-positive lobules were 7\u2005mm away from the high-grade DCIS and was 1.1\u2005mm in size. These HER2-positive lobules showed no histologic abnormality and had no difference compared with the surrounding normal TDLUs. Nevertheless, in addition to showing HER2 overexpression in IHC,\n                    <jats:italic toggle=\"yes\">HER2<\/jats:italic>\n                    amplification was also identified in HER2 silver\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    hybridization.\n                    <jats:italic toggle=\"yes\">HER2<\/jats:italic>\n                    amplification plays an important role in breast cancer development, and HER2 amplification is known to occur as an early event in cancer development. There have been studies identifying driver mutations in normal tissues of other organs. These findings suggest that\n                    <jats:italic toggle=\"yes\">HER2<\/jats:italic>\n                    amplification in the breast without histological abnormality could occur, and the HER2-positive lobules could be \u201cat risk\u201d for transformation into the precursor lesion of HER2-positive breast cancer, although the biological significance of these findings is unclear.\n                  <\/jats:p>","DOI":"10.1177\/10668969221137514","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T02:16:10Z","timestamp":1669601770000},"page":"801-804","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case Report of\n                    <i>HER2<\/i>\n                    -Amplification in the Breast Without Histological Abnormality"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6385-7621","authenticated-orcid":false,"given":"Miseon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"},{"name":"Cancer Research Institute, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11412"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61539-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03568.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2808"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(00)00252-0"},{"issue":"8","key":"e_1_3_2_7_2","first-page":"1727","article-title":"A genetic explanation of Slaughter\u2019s concept of field cancerization: evidence and clinical implications","volume":"63","author":"Braakhuis BJ","year":"2003","unstructured":"Braakhuis BJ, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH. A genetic explanation of Slaughter\u2019s concept of field cancerization: evidence and clinical implications. Cancer Res. 2003;63(8):1727\u20101730.","journal-title":"Cancer Res"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000038462.62634.B1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20275"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3391"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880503"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.8.737"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02888.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.2.267"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1672-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa6806"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau3879"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.037"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2214-z"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3733"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408617"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.02.005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409405"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221137514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969221137514","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221137514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:59:43Z","timestamp":1787759983000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969221137514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,27]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1177\/10668969221137514"],"URL":"https:\/\/doi.org\/10.1177\/10668969221137514","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969221137514\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969221137514\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969221137514\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969221137514\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969221137514\/v1\/review1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,27]]}}}