{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:18:48Z","timestamp":1787811528221,"version":"build-2784847793"},"reference-count":19,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    Hyalinizing clear cell carcinomas of tracheobronchial origin are very rare salivary gland type tumors accounting for less than 1% of lung tumors with only 13 cases reported to date. Their radiological features, morphological spectrum, and molecular features are not well described.\n                    <jats:italic toggle=\"yes\">Aim:<\/jats:italic>\n                    To perform a clinicopathological analysis of primary pulmonary hyalinizing clear cell carcinomas.\n                    <jats:italic toggle=\"yes\">Method:<\/jats:italic>\n                    A retrospective search of primary pulmonary hyalinizing clear cell carcinomas was conducted from authors\u2019 institutions and the clinicopathological features including details of molecular testing were analyzed.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    Five primary pulmonary hyalinizing clear cell carcinomas were identified. The mean patient age at diagnosis was 48.2 years (range: 33-64 years). Three patients were women. All patients were nonsmokers and 3 were symptomatic; 2 were detected incidentally during health screening. The tumors were located in the main lobar bronchi ranging from 1.3 to 4.9\u2005cm in maximum dimension. Microscopy showed cords and nests of at least, focally clear tumor cells. Mucin cysts lacking goblet cells were seen. All tumors were uniformly positive for p40, p63, AE1\/AE3, keratin 7, and epithelial membrane antigen but negative for TTF1, KIT, neuroendocrine markers, and other myoepithelial markers. All cases showed Ewing sarcoma breakpoint region 1 (\n                    <jats:italic toggle=\"yes\">EWSR1<\/jats:italic>\n                    ) gene rearrangement. Perineural invasion and lymph node metastases were detected in patient 5. Two patients with available follow-up data were recurrence-free until 4 years (patient 1) and 9 months (patient 5) after resection.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    The present series adds to the scant available literature on primary pulmonary hyalinizing clear cell carcinomas highlighting the characteristic histomorphology, immunoprofiles, and benign outcomes of these rare tumors.\n                  <\/jats:p>","DOI":"10.1177\/10668969221137516","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T01:30:31Z","timestamp":1670981431000},"page":"1187-1194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Primary Pulmonary Hyalinizing Clear Cell Carcinoma: Case Series With Review of Literature"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6122-409X","authenticated-orcid":false,"given":"Shilpi","family":"Thakur","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Nambirajan","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon T.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology"},{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen M.","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology"},{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja C.","family":"Roden","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Kumar","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-9814","authenticated-orcid":false,"given":"Deepali","family":"Jain","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"issue":"1","key":"e_1_3_2_2_2","article-title":"Hyalinizing clear cell carcinoma of salivary gland: a review and update","volume":"7","author":"Weinreb I","year":"2013","unstructured":"Weinreb I. Hyalinizing clear cell carcinoma of salivary gland: a review and update. Head Neck Pathol. 2013;7(Suppl 1):S20-S29.","journal-title":"Head Neck Pathol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199401000-00007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.11.010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12636"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0820-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.04.011"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx048"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0025-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.09.009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24285"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-022-01216-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001114"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23974"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.291085126"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2017.02.007"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31828a6727"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0427-2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01204-5"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24637"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221137516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969221137516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969221137516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:39:20Z","timestamp":1787809160000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969221137516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/10668969221137516"],"URL":"https:\/\/doi.org\/10.1177\/10668969221137516","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]}}}