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Radiological and gross findings cannot distinguish leiomyoadenomatoid tumors from the more common classic adenomatoid tumors or leiomyomas, and careful microscopic examination is critical in the identification of this esoteric variant. The histogenesis of this entity remains ambiguous. Common hypotheses include a collision tumor, a variant of an adenomatoid tumor with a smooth muscle component, or an adenomatoid tumor arising in the background of reactive smooth muscle hyperplasia. We present 2 cases of leiomyoadenomatoid tumors with diffuse nuclear WT1 positivity in both the adenomatoid and smooth muscle components, supporting the mesothelial origin of these tumors.<\/jats:p>","DOI":"10.1177\/10668969221137521","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:50:10Z","timestamp":1670374210000},"page":"866-871","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Diffuse WT1 Positivity in Smooth Muscle Component Supports Dual Differentiation of Mesothelial Cells in the Histogenesis of Leiomyoadenomatoid Tumors\u2014A Report of two Cases"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-0150","authenticated-orcid":false,"given":"Kritika","family":"Krishnamurthy","sequence":"first","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yekaterina","family":"Merkulova","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaileen","family":"Guzman-Arocho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seymour","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2020.101226"},{"key":"e_1_3_2_3_2","first-page":"137","article-title":"Adenomatoid tumors of the epididymis and testicle: report of 9 cases and bibliographic reviews","volume":"62","author":"Alvarez Maestro M","year":"2009","unstructured":"Alvarez Maestro M, Tur Gonzalez R, Alonso Dorrego JM, Jesus De la Pena Barthel J, Nistal Martin de Serrano M. 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