{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:11:44Z","timestamp":1787890304015,"version":"build-2784847793"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    Rhabdomyosarcoma affects mainly pediatric patients and is currently classified into four categories: embryonal, alveolar, pleomorphic, and spindle cell\/sclerosing. Recently, a molecular group of spindle cell\/sclerosing rhabdomyosarcoma demonstrated new fusion transcripts involving\n                    <jats:italic toggle=\"yes\">FET<\/jats:italic>\n                    -family genes with\n                    <jats:italic toggle=\"yes\">TFCP2<\/jats:italic>\n                    . In this report, we describe a rare case of spindle cell\/sclerosing rhabdomyosarcoma in a 19-year-old woman, presenting as a destructive lesion involving the condyle of mandible. Next generation sequencing was performed, revealing a\n                    <jats:italic toggle=\"yes\">FUS::TFCP2<\/jats:italic>\n                    fusion and deletion of\n                    <jats:italic toggle=\"yes\">ALK<\/jats:italic>\n                    gene. Alectinib therapy was initiated, which resulted in a favorable response for 4 months. However, the patient died due progression of the tumor. To make an accurate diagnosis and ensure appropriate patient management, it is necessary to be aware of this variant and use proper immunohistochemical stains when facing malignant mesenchymal bone lesions, expanding its differential diagnosis.\n                  <\/jats:p>","DOI":"10.1177\/10668969221140397","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T01:09:05Z","timestamp":1670375345000},"page":"861-865","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Intraosseous Spindle Cell\/Epithelioid Rhabdomyosarcoma with\n                    <i>TFCP2<\/i>\n                    Rearrangement: A Recent Recognized Subtype with Partial Response to Alectinib"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-8404","authenticated-orcid":false,"given":"Ediel","family":"Val\u00e9rio","sequence":"first","affiliation":[{"name":"Department of Pathology, A.C. Camargo Cancer Center, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Logan","family":"Furtado Costa","sequence":"additional","affiliation":[{"name":"Department of Pathology, DASA Laboratories, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Moreno","family":"Perez Fraile","sequence":"additional","affiliation":[{"name":"Santa Paula Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Haydn","family":"Credidio","sequence":"additional","affiliation":[{"name":"Department of Pathology, DASA Laboratories, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Ricardo","family":"Taveira Garcia","sequence":"additional","affiliation":[{"name":"Department of Radiology, DASA Laboratories, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristovam Scapulatempo","family":"Neto","sequence":"additional","affiliation":[{"name":"Pathology and Molecular Diagnostics (GeneOne), DASA Laboratories, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe D\u2019Almeida","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Pathology, A.C. Camargo Cancer Center, S\u00e3o Paulo, Brazil"},{"name":"Department of Pathology, DASA Laboratories, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"601","volume-title":"Enzinger and Weiss\u2019s soft tissue tumors","author":"Goldblum JR","year":"2014","unstructured":"Goldblum JR, Folpe AL, Weiss SW. Enzinger and Weiss\u2019s soft tissue tumors. 6th ed. Philadelphia: Elsevier Saunders; 2014;601\u2013603.","edition":"6"},{"key":"e_1_3_3_3_2","first-page":"201","volume-title":"WHO Classification of Tumours. World Health Organization classification of tumours: soft tissue and bone tumours","author":"World Health Organization (WHO)","year":"2020","unstructured":"World Health Organization (WHO). WHO Classification of Tumours. World Health Organization classification of tumours: soft tissue and bone tumours. 5th ed. 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