{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:26:34Z","timestamp":1787761594940,"version":"build-2784847793"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Open Foundation of Hubei Key Laboratory of Tumor Environment and Immunotherapy of China","award":["2018 KZL03"],"award-info":[{"award-number":["2018 KZL03"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81772833"],"award-info":[{"award-number":["81772833"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    Solitary fibrous tumor (SFT) is an uncommon fibroblastic neoplasm which may arise in a wide range of anatomic location and can occur across all ages. Fat-forming SFT is a rare morphological variant of SFT. Primary breast fat-forming SFT is exquisitely rare. Here, we report a case in a 51-year-old Chinese woman with a palpable painless mass in the left breast. A color Doppler ultrasound scan examination demonstrated a 3.4-cm oval, well-circumscribed, hypoechoic solid mass with several peripheral and internal color flow signals. Magnetic resonance imaging (MRI) showed a focal lobulated solid nodular lesion displaying geographical enhancement but no architectural distortion. Subsequently, she underwent a left breast lumpectomy. In histopathologic examination, there was a well-circumscribed, cellular spindle cell tumor consisting of short fascicles of bland, fusiform, ovoid to spindle cells disposed in a patternless architecture around branching vascular spaces within a fibrous stroma with wispy collagen. Cells revealed mild nuclear atypia. Mitotic figures were up to 4\/10 high-power fields (HPFs) in the hot spot. Mature adipocytes intermixed with spindle cells were also observed. The tumor cells were diffusely positive for CD34 and STAT6. Some S100-expressing adipocytes co-expressed STAT6. Next-generation sequencing (NGS) revealed the presence of the\n                    <jats:italic toggle=\"yes\">NAB2exon6::STAT6exon2<\/jats:italic>\n                    fusion. The histological, immunohistochemical (IHC) and molecular examinations confirmed the diagnosis of fat-forming SFT. Post-excision, the patient showed no signs of tumor recurrence or metastasis in a 7-month follow-up. Here, we describe a rare case of a fat-forming SFT involving the breast and highlight the comprehensive pathological evaluation and necessary ancillary testing.\n                  <\/jats:p>","DOI":"10.1177\/10668969221143475","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T01:52:35Z","timestamp":1670464355000},"page":"830-838","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-5941","authenticated-orcid":false,"given":"Yufei","family":"Liu","sequence":"first","affiliation":[{"name":"Pathology Institute of China, Three Gorges University, Yichang, China"},{"name":"Department of Pathology, Yichang Central People's Hospital, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pathology Institute of China, Three Gorges University, Yichang, China"},{"name":"Department of Pathology, Yichang Central People's Hospital, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tai He Hospital, Hubei University of Medicine, Shiyan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Cao","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Tumor Environment and Immunotherapy, China Three Gorges University Medical College, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Diagnosis, Yichang Central People's Hospital, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yichang Central People's Hospital, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-021-01095-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000524364"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.14175"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13537"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2018-205561"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/2632010X19868462"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13583"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2019.22.e30"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12841"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5812\/iranjradiol.65607"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12925"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2018.07.011"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.06.015"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2015.12.013"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-001-0572-y"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00985-3.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13131"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22415"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-015-0674-9"},{"issue":"10","key":"e_1_3_3_21_2","first-page":"13166","article-title":"Immunohistochemical detection of STAT6, CD34, CD99 and BCL2 for diagnosing solitary fibrous tumors\/hemangiopericytomas","volume":"8","author":"Han Y","year":"2015","unstructured":"Han Y, Zhang Q, Yu X, et al. 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