{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:47:30Z","timestamp":1788468450091,"version":"build-2803163510"},"reference-count":47,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    Primary renal synovial sarcoma is a rare aggressive mesenchymal neoplasm of the kidney that accounts for less than 1% of renal sarcomas. Herein, we describe the clinicopathologic and molecular findings of 14 renal synovial sarcoma patients in one of the largest case series to date and to our knowledge, the only renal synovial sarcoma series to use novel SS18-SSX IHC. Clinicopathologic, IHC, molecular, management, and follow-up data were reviewed and analyzed. Macroscopically, the tumors had either homogeneous, tan-white, and solid (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200910), variegated and solid (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20093), or variegated and solid-cystic (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20091) cut surfaces. Spindle cell (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200910), round cell (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20093), and round to epithelioid morphologies (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20091) were observed. SS18-SSX IHC was positive in all 14 tumors (diffuse,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200910; multifocal,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20092; focal,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20092). All the tumors harbored\n                    <jats:italic toggle=\"yes\">SS18::SSX1\/2<\/jats:italic>\n                    gene rearrangement. Metastases to the liver, brain, and lung (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20091); liver and bone (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20091); liver and diaphragm (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20091) were identified. Adjuvant chemotherapy was administered in 11\/12 patients. Follow-up was available for 10 patients (time period range: 5 to 24 months). Four patients died of disease, and six patients are alive with no recurrence or metastasis. As SS18-SSX IHC showed an excellent concordance with the FISH results, this may reliably be used in the IHC panel of spindle\/round cell sarcomas of the kidney and as a molecular surrogate for renal synovial sarcoma, particularly in a resource-limited setting. Also, the tumors with focal SS18-SSX expression had lower break apart signals in the FISH assay (19% and 23% in two tumors with focal SS18-SSX IHC positivity).\n                  <\/jats:p>","DOI":"10.1177\/10668969221143481","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T06:44:48Z","timestamp":1672641888000},"page":"1232-1243","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["SS18-SSX Expression in a Contemporary Cohort of Primary Renal Synovial Sarcoma: A Multi-Institutional Experience of Fourteen Patients"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-5900","authenticated-orcid":false,"given":"Bindu","family":"Challa","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-2424","authenticated-orcid":false,"given":"Sambit K.","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, Advanced Medical and Research Institute, Bhubaneswar, India"},{"name":"Departments of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpy","family":"Jha","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, Advanced Medical and Research Institute, Bhubaneswar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakul Y.","family":"Sampat","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, Advanced Medical and Research Institute, Bhubaneswar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhani","family":"Sardana","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-8009","authenticated-orcid":false,"given":"Anandi","family":"Lobo","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, Kapoor Center of Urology and Pathology, Raipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Sharma","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samriti","family":"Arora","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debadarshi","family":"Rath","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, Advanced Urology Maxport Hospital, Bhubaneswar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri","family":"Munjal","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niharika","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, Advanced Medical and Research Institute, Bhubaneswar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Jain","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, CORE Diagnostics, Gurgaon, 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