{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:07:59Z","timestamp":1792181279173,"version":"4.4.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Introduction.<\/jats:italic>\n                    Sialadenoma papilliferum (SP) is a rare benign neoplasm that usually arises in the minor salivary glands. Recently, it was demonstrated that SP shares similar molecular genetic alterations (\n                    <jats:italic toggle=\"yes\">BRAF V600E<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">HRAS<\/jats:italic>\n                    mutations) with its morphologic analog, syringocystadenoma papilliferum.\n                    <jats:italic toggle=\"yes\">Methods.<\/jats:italic>\n                    We sought to perform clinicopathologic and immunophenotypic (BRAF V600E and SOX10) analyses on 8 new cases of SP.\n                    <jats:italic toggle=\"yes\">Results.<\/jats:italic>\n                    The cases were from 4 males and 4 females, with ages ranging from 28 to 81 years (average: 64 years). The common locations were the hard palate (n\u2009=\u20093) and buccal mucosa (n\u2009=\u20093). Histopathologically, 7 cases were classic and 1 case was oncocytic. BRAF V600E immunohistochemistry (IHC) was positive in all classic SP, involving both the exophytic and endophytic components, but negative in the oncocytic SP. SOX10 was positive in the endophytic ductal cells of the evaluated classic SP but was negative in the oncocytic SP.\n                    <jats:italic toggle=\"yes\">Conclusions.<\/jats:italic>\n                    We report 8 new cases of this rare salivary gland neoplasm, using BRAF V600E and SOX10 IHC to further support the following points: (1) the functional role of\n                    <jats:italic toggle=\"yes\">BRAF V600E<\/jats:italic>\n                    mutation, RAS\/mitogen-activated protein kinase signaling pathway in the pathogenesis of classic SP of salivary glands by IHC; (2) the analogous relationship between SP, syringocystadenoma papilliferum, and papillary seromucinous adenocarcinoma with sinonasal papilloma-like surface component (PSASP-like surface); (3) endophytic ductal component in classic SP arises from the intercalated ducts and not the excretory ducts; and (4) oncocytic SP is distinct from classic SP.\n                  <\/jats:p>","DOI":"10.1177\/10668969221147170","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T01:16:42Z","timestamp":1673486202000},"page":"1265-1272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinicopathologic Study of Sialadenoma Papilliferum of the Minor Salivary Glands: A Series of 8 New Cases With BRAF V600E Mutation-specific Immunohistochemical Analysis"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4602-9469","authenticated-orcid":false,"given":"Adepitan A.","family":"Owosho","sequence":"first","affiliation":[{"name":"The University of Tennessee Health Science Center"},{"name":"The University of Tennessee Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alivia M.","family":"Shasteen","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Aguirre","sequence":"additional","affiliation":[{"name":"The University of Tennessee Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt F.","family":"Summersgill","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196911)24:5<1057::AID-CNCR2820240529>3.0.CO;2-L"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01068-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13990"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-021-01084-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.115978"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0852-8"},{"issue":"9","key":"e_1_3_2_8_2","article-title":"Sialadenoma papilliferum: bibliometric analysis","volume":"11","author":"de Vasconcelos Ii AJ","year":"2019","unstructured":"de Vasconcelos Ii AJ, Gerber LR, Saraiva SH, et al. 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