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Immunohistochemical stains were notable for expression of enteric markers (CDX2 and KRT20), as well as negativity for Mullerian markers (PAX8, ER, and PR), diffuse expression for p16, and positivity for high-risk HPV mRNA expression. Ultimately, a diagnosis of vaginal primary HPV-associated enteric type adenocarcinoma was rendered for this unusual lesion. To our knowledge, no prior cases of HPV-associated enteric type adenocarcinomas of the vagina have been described before.<\/jats:p>","DOI":"10.1177\/10668969221150529","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T01:03:33Z","timestamp":1674608613000},"page":"1393-1397","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary HPV-Associated Enteric-Type Adenocarcinoma of Vagina: A Case Report"],"prefix":"10.1177","volume":"31","author":[{"given":"Christopher","family":"Felicelli","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Strickland","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-2793","authenticated-orcid":false,"given":"Jian-Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine"},{"name":"Northwestern University Feinberg School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"issue":"1","key":"e_1_3_2_2_2","first-page":"1","article-title":"Intrauterine diethylstilbestrol exposure and its consequences: pathologic characteristics of vaginal adenosis, clear cell adenocarcinoma, and related lesions","volume":"101","author":"Robboy SJ","year":"1977","unstructured":"Robboy SJ, Scully RE, Welch WR, Herbst AL. 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