{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:18:44Z","timestamp":1787811524221,"version":"build-2784847793"},"reference-count":14,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    Biphenotypic sinonasal sarcoma is a newly established tumor entity that is associated with distinct clinicopathological findings. Biphenotypic sinonasal sarcoma is a rare, low-grade spindle cell sarcoma that arises in middle-aged females, exclusively in the sinonasal tract. A fusion gene involving\n                    <jats:italic toggle=\"yes\">PAX3<\/jats:italic>\n                    is detected in most biphenotypic sinonasal sarcomas, which aids in its diagnosis. Here, we report a case of biphenotypic sinonasal sarcoma with its cytological findings. The patient was a 73-year-old woman who presented with purulent nasal discharge and dull pain in the left cheek area. Computed tomography showed a mass extending from the left nasal cavity to the left ethmoid sinus, the left frontal sinus, and the frontal skull base. She underwent a combined transcranial and endoscopic approach for en bloc resection with a safety margin. Histologically, spindle-shaped tumor cells have been thought to proliferate mainly in the subepithelial stroma. Here, nasal mucosal epithelial hyperplasia was noted, and the tumor had invaded the bone tissue accompanying the epithelial cells. Fluorescence\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    hybridization (FISH) analysis showed a\n                    <jats:italic toggle=\"yes\">PAX3<\/jats:italic>\n                    rearrangement, and next-generation sequencing identified a\n                    <jats:italic toggle=\"yes\">PAX3::MAML3<\/jats:italic>\n                    fusion. Based on FISH, split signals were observed not in respiratory cells but in stromal cells. This indicated that respiratory cells were non-neoplastic. In the diagnosis of biphenotypic sinonasal sarcoma, the inverted growth of the respiratory epithelium can be a diagnostic pitfall. FISH analysis using a\n                    <jats:italic toggle=\"yes\">PAX3<\/jats:italic>\n                    break-apart probe is helpful not only for an accurate diagnosis but also for detecting the true neoplastic cells.\n                  <\/jats:p>","DOI":"10.1177\/10668969231152577","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T01:34:48Z","timestamp":1676856888000},"page":"1414-1419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Biphenotypic Sinonasal Sarcoma: A Genetically Confirmed Case Showing Bone Invasion Accompanying a Non-neoplastic Respiratory Epithelium"],"prefix":"10.1177","volume":"31","author":[{"given":"Erika","family":"Muraoka","sequence":"first","affiliation":[{"name":"Yokohama City University Hospital"},{"name":"Yokohama City University, Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-9509","authenticated-orcid":false,"given":"Ikuma","family":"Kato","sequence":"additional","affiliation":[{"name":"Yokohama City University, Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Yokohama City University, Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Arai","sequence":"additional","affiliation":[{"name":"Yokohama City University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Suenaga","sequence":"additional","affiliation":[{"name":"Yokohama City University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Yokohama City University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Yokohama City University Hospital"},{"name":"Yokohama City University, Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182426886"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2989"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0207-RA"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22295"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000492"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13045"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001238"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01479-w"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.10.007"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12102528"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2017.11.005"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145561321999196"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24142"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1667146"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231152577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231152577","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231152577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:39:13Z","timestamp":1787809153000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231152577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,19]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/10668969231152577"],"URL":"https:\/\/doi.org\/10.1177\/10668969231152577","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969231152577\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969231152577\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,19]]}}}