{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:18:44Z","timestamp":1787811524302,"version":"build-2784847793"},"reference-count":14,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>BRCA1-associated protein 1 (BAP1)-inactivated melanomas can occur sporadically or in germline contexts, particularly in recently recognized BAP1-tumor predisposition syndrome. Diagnosis represents a clinical and histopathological challenge, requiring comprehensive analysis of morphology and sometimes molecular analysis in addition to immunohistochemistry. We report a BAP1-inactivated cutaneous melanoma initially diagnosed as an atypical Spitz tumor on the auricle in a patient with BAP1-tumor predisposition syndrome. Immunohistochemistry, fluorescence in situ hybridization, and comparative genomic hybridization allowed diagnosis. Cutaneous BAP1-inactivated melanocytic tumors, previously classified as atypical Spitz Nevi, may have a dermal mitotic activity that can resemble melanoma and on the other hand, atypical Spitz tumors are sometimes difficult to differentiate from BAP1-inactivated melanoma. Specific criteria, requiring molecular diagnosis have been proposed in order to support melanoma diagnosis.<\/jats:p>","DOI":"10.1177\/10668969231152579","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T01:34:52Z","timestamp":1676856892000},"page":"1398-1402","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Difficult to Diagnose Cutaneous Melanoma in a Patient with BAP1 Tumor Predisposition Syndrome"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-265X","authenticated-orcid":false,"given":"Francisca","family":"Silva-Claver\u00eda","sequence":"first","affiliation":[{"name":"Melanoma Unit, Department of Medical &amp; Surgical Dermatology, University Hospital Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"\u00c1lvarez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Pathology Department, University Hospital Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Ferr\u00e1ndiz","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Department of Medical &amp; Surgical Dermatology, University Hospital Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Fern\u00e1ndez-Orland","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Department of Medical &amp; Surgical Dermatology, University Hospital Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Felix","family":"Conde-Martin","sequence":"additional","affiliation":[{"name":"Pathology Department, University Hospital Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Moreno-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Department of Medical &amp; Surgical Dermatology, University Hospital Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6346-0061","authenticated-orcid":false,"given":"Juan J.","family":"R\u00edos-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Pathology Department, University Hospital Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"Jensen DE Proctor M Marquis ST et al. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING \u00aenger and enhances BRCA1-mediated cell growth suppression. 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