{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:25:04Z","timestamp":1787761504102,"version":"build-2784847793"},"reference-count":23,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Natural Science Foundation Project of Chongqing","award":["cstc2019jcyj-msxmX0447"],"award-info":[{"award-number":["cstc2019jcyj-msxmX0447"]}]},{"name":"Basic Research and Frontier exploration project of Chongqing Yuzhong District","award":["20210163"],"award-info":[{"award-number":["20210163"]}]},{"name":"Special key projects for technological innovation and application development of Chongqing","award":["2022TIAD-KPX0243"],"award-info":[{"award-number":["2022TIAD-KPX0243"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n                    GLI1-altered mesenchymal tumor is an emerging entity with distinctive clinicopathologic features. It shows a distinctive monomorphic round to epithelioid morphology, nested to trabecular pattern of growth, and S100+\/SOX10-\/SMA-immunophenotype. We report an example of this entity arising in the duodenum. A 31-year-old man presented with anemia for 1 year, a mass in the duodenal bulb was found for 9 days. Histopathologic examination revealed the tumor with distinct multilobulated architecture, a monomorphic appearance of round to epithelioid cells arranged in papillary structures, nests, cords, solid, reticular patterns, and hyalinized stroma surrounding a rich capillary network. The neoplastic cells had amphophilic to light eosinophilic or clear cytoplasm, uniform round nuclei with fine chromatin and inconspicuous nucleoli. Immunohistochemical analysis revealed strong positivity for vimentin, S100, CD56, CyclinD1, and negativity for SOX10, SMA, melan-A, HMB-45, synaptophysin, and a variety of other markers. Based on the morphology and immunophenotype, molecular studies were performed, which revealed the presence of an\n                    <jats:italic toggle=\"yes\">ACTB<\/jats:italic>\n                    ::\n                    <jats:italic toggle=\"yes\">GLI1<\/jats:italic>\n                    fusion transcript, confirming the diagnosis of GLI1-altered mesenchymal tumor.\n                  <\/jats:p>","DOI":"10.1177\/10668969231157782","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T01:27:55Z","timestamp":1677634075000},"page":"1538-1547","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["GLI1-altered Mesenchymal Tumor Involving the Duodenum: Case Report and Literature Review"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-4382","authenticated-orcid":false,"given":"Ying","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Pathology, Chongqing General Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-7687","authenticated-orcid":false,"given":"Hui","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chongqing General Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chongqing General Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-715X","authenticated-orcid":false,"given":"Xuefeng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chongqing General Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chongqing General Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0293-x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03224-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63723-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.01.019"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.02.015"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000542"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001360"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001439"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2021.10.007"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14065"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896919900548"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.07.013"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14235"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14280"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.7058"},{"key":"e_1_3_3_18_2","article-title":"Epithelioid soft tissue neoplasm of the soft palate with a PTCH1-GLI1 fusion: a case report and review of the literature","author":"Klubickova N","unstructured":"Klubickova N, Kinkor Z, Michal M, et al. Epithelioid soft tissue neoplasm of the soft palate with a PTCH1-GLI1 fusion: a case report and review of the literature. Head Neck Pathol. 2022;16(2):621-630.","journal-title":"Head Neck Pathol"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22916"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001844"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-022-01679-0"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14152"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.68"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4730"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231157782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231157782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231157782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:56:51Z","timestamp":1787759811000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231157782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,28]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/10668969231157782"],"URL":"https:\/\/doi.org\/10.1177\/10668969231157782","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,28]]}}}