{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:25:04Z","timestamp":1787761504125,"version":"build-2784847793"},"reference-count":15,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n                    Myxofibrosarcoma is a malignant fibroblastic neoplasm that commonly arises in the extremities, with mediastinum being a very rare location. The development of sarcomas is uncommon in patients with Lynch syndrome. We present a Lynch syndrome patient with synchronous cecal adenocarcinoma and mediastinal myxofibrosarcoma with both harboring the same loss-of-function\n                    <jats:italic toggle=\"yes\">MSH2<\/jats:italic>\n                    alteration (c.2634\u2009+\u20091G\u2009&gt;\u2009A splice region variant). Metastatic myxofibrosarcoma in the left chest wall developed 6 months after the initial diagnosis. The clinical presentation, imaging findings, histopathology, and molecular studies along with differential diagnoses are presented and discussed.\n                  <\/jats:p>","DOI":"10.1177\/10668969231166299","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T02:26:32Z","timestamp":1680575192000},"page":"1605-1609","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Mediastinal Myxofibrosarcoma Harboring Loss-of-Function\n                    <i>MSH2<\/i>\n                    Variant in a Patient With Lynch Syndrome: A Case Report and Literature Review"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-6428","authenticated-orcid":false,"given":"Liwei","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Pathology"},{"name":"UT Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pathology"},{"name":"UT Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"De Las Casas","sequence":"additional","affiliation":[{"name":"Department of Pathology"},{"name":"UT Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Soft Tissue and Bone Tumours WHO Classification of Tumours","year":"2022","unstructured":"WHO Classification of Tumours Editorial Board. Soft Tissue and Bone Tumours WHO Classification of Tumours. 5th Edition. Lyon, France: International Agency for Research on Cancer, 2022, p. 3.","edition":"5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199604000-00001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1341-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-5063-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2787"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800550"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.034942"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0202-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182367aa7"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10419"},{"issue":"9","key":"e_1_3_2_12_2","article-title":"Sarcoma: an unusual tumor in a patient with Lynch syndrome","volume":"73","author":"Leo QJN","year":"2014","unstructured":"Leo QJN, Bolger D. Sarcoma: an unusual tumor in a patient with Lynch syndrome. Hawaii J Med Public Health. 2014;73(9 Suppl 1):49-49.","journal-title":"Hawaii J Med Public Health"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.33.15_suppl.1516"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14377"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.08.018"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.171"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231166299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231166299","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231166299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:56:55Z","timestamp":1787759815000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231166299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/10668969231166299"],"URL":"https:\/\/doi.org\/10.1177\/10668969231166299","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]}}}