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We present an 82-year-old woman with a history of pelvic organ prolapse-associated urinary symptoms. The patient was found to have pigmented urinary bladder mucosa on cystoscopy and underwent a total hysterectomy and bladder mucosal biopsy. Histologically, pigmented granules were evident in the bladder stroma and epithelium, highlighted by Periodic Acid-Schiff (PAS) stain, suggestive of lipofuscin in nature. We outline the diagnostic features of bladder melanosis, discuss the diagnostic mimickers, and thoroughly review the literature on the subject.<\/jats:p>","DOI":"10.1177\/10668969231166301","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T03:59:26Z","timestamp":1680667166000},"page":"104-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Urinary Bladder \u201cMelanosis\u201d: A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"32","author":[{"given":"Qi","family":"Cao","sequence":"first","affiliation":[{"name":"University of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"University of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Aron","sequence":"additional","affiliation":[{"name":"University of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-7168","authenticated-orcid":false,"given":"Tiannan","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913129009076140"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325996"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-002-0614-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00695062"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059638"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(79)90087-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197604)37:4<1928::AID-CNCR2820370444>3.0.CO;2-W"},{"key":"e_1_3_2_9_2","unstructured":"Kojima T Tanaka T Yoshimi N Mori H. 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