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Tumor cells showed prominent nucleoli and perinucleolar halos. Aberrant diffuse (&gt;90%), strong, and membranous carbonic anhydrase 9 and variable GATA3 expression were present. Diagnostic loss of fumarate hydratase expression and 2-succinyl cysteine overexpression (cytoplasmic and nuclear) were identified. Carbonic anhydrase 9 and GATA3 expression in FHRCC is rarely reported in the literature, and may cause misdiagnosis of clear cell RCC and\/or urothelial carcinoma.<\/jats:p>","DOI":"10.1177\/10668969231167486","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T01:15:55Z","timestamp":1681348555000},"page":"145-149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Diffuse Carbonic Anhydrase 9 and GATA3 Expression in Fumarate Hydratase Deficient Renal Cell Carcinoma \u2013 A Case Report and Immunoprofile Review"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9919-7290","authenticated-orcid":false,"given":"Richard R.","family":"Pacheco","sequence":"first","affiliation":[{"name":"Albany Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Albany Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cooley","sequence":"additional","affiliation":[{"name":"Albany Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Albany Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0929-0940","authenticated-orcid":false,"given":"Mahmut","family":"Akgul","sequence":"additional","affiliation":[{"name":"Albany Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.06.016"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000617"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051633798"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001372"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.12.013"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13183"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000321"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969211026241"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969221074600"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14204"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231167486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231167486","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231167486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:09:07Z","timestamp":1787645347000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231167486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,12]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1177\/10668969231167486"],"URL":"https:\/\/doi.org\/10.1177\/10668969231167486","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,12]]}}}