{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:27:11Z","timestamp":1787646431839,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                    Development of mesothelioma is associated with asbestos exposure. Common presentations are with pleural-based plaques invading the chest wall and\/or pleural effusion on chest imaging. The intent of this case report is to describe a rare presentation of mesothelioma, which presented atypically as a large tension pneumothorax. A 93-year-old male presented with a history of dyspnea that started after a coughing episode. On physical examination he was hemodynamically stable, but was hypoxic requiring 2L of supplemental oxygen. Computed tomography of the chest revealed a large right tension pneumothorax. A chest tube was placed and connected to suction (\u221220cmH\n                    <jats:sub>2<\/jats:sub>\n                    0), but he continued to have an unresolving air leak over the following 2-week period. Upon video-assisted thoracotomy there were no blebs or adhesions seen. Right apical wedge resection and talc pleurodesis were performed. Pathologic examination revealed an atypical mesothelial cell proliferation with minimal, focal invasion into the pulmonary parenchyma. Tumor spread along the visceral pleura was thought to be the underlying cause of the pneumothorax. The surgical margins were uninvolved by the tumor, and the patient was later discharged home in stable condition. This was a rare presentation of what could best be described as minimally invasive mesothelioma arising in a background of probable mesothelioma in situ, which presented atypically as a large tension pneumothorax. This case highlighted the importance of establishing a pathologic diagnosis from pleural effusion cytology and\/or pleural biopsy in persons presenting with spontaneous pneumothorax, and the difficulty in confirming a pathologic diagnosis of early mesothelial neoplasia.\n                  <\/jats:p>","DOI":"10.1177\/10668969231167492","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T02:14:15Z","timestamp":1682993655000},"page":"109-114","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Presentation of Minimally Invasive Mesothelioma as a Large Tension Pneumothorax"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-5466","authenticated-orcid":false,"given":"Tanya","family":"Marshall","sequence":"first","affiliation":[{"name":"Cleveland Clinic Akron General"},{"name":"Allegheny General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Lane","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Akron General"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lahorra","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Akron General"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.84"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2019.03.001"},{"issue":"1","key":"e_1_3_2_4_2","article-title":"Mesothelioma developing in carriers of inherited genetic mutations","volume":"9","author":"Yoshikawa Y","year":"2020","unstructured":"Yoshikawa Y, Emi M, Nakano T, et al. Mesothelioma developing in carriers of inherited genetic mutations. Transl Lung Cancer Res. 2020;9(Suppl 1):S67\u2010S76.","journal-title":"Transl Lung Cancer Res"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2018.02.006"},{"key":"e_1_3_2_6_2","first-page":"43","article-title":"Recurrent hydropneumothorax: an unusual presentation for malignant pleural mesothelioma","volume":"19","author":"DeLapp D","year":"2016","unstructured":"DeLapp D, Chan C, Nystrom P. Recurrent hydropneumothorax: an unusual presentation for malignant pleural mesothelioma. Respir Med Case Rep. 2016;19:43\u201045.","journal-title":"Respir Med Case Rep"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.125"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13877"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-008-0067-z"},{"issue":"2","key":"e_1_3_2_10_2","article-title":"The genetic susceptibility in the development of malignant pleural mesothelioma","volume":"10","author":"Melaiu O","year":"2018","unstructured":"Melaiu O, Gemignani F, Landi S. The genetic susceptibility in the development of malignant pleural mesothelioma. J Thorac Dis. 2018;10(Suppl 2):S246\u2010S252.","journal-title":"J Thorac Dis"},{"key":"e_1_3_2_11_2","unstructured":"Sauter JL Bueno R Dacic S et al. Diffuse pleural mesothelioma. In: WHO Classification of Tumours Editorial Board. Thoracic tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2021 [cited 2022 September 19]. (WHO classification of tumours series 5th ed.; vol. 5). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/35."},{"key":"e_1_3_2_12_2","unstructured":"Mandelker D Ladanyi M Sauter JL. BAP1 tumour predisposition syndrome. In: WHO Classification of Tumours Editorial Board. Thoracic tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2021 [cited 2022 September 19]. (WHO classification of tumours series 5th ed.; vol. 5). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/35."},{"key":"e_1_3_2_13_2","unstructured":"Dacic S de Perrot M Gill RR et al. Mesothelioma in situ. In: WHO Classification of Tumours Editorial Board. Thoracic tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2021 [cited 2022 September 19]. (WHO classification of tumours series 5th ed.; vol. 5). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/35."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu227"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0295"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy171"},{"key":"e_1_3_2_17_2","unstructured":"Khoor A Bironzo P Bueno R et al. Localized pleural mesothelioma. In: WHO Classification of Tumours Editorial Board. Thoracic tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2021 [cited 2022 September 19]. (WHO classification of tumours series 5th ed.; vol. 5). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/35."},{"issue":"5","key":"e_1_3_2_18_2","first-page":"608","article-title":"The 2021 WHO classification of tumors of the pleura: advances since the 2015 classification","volume":"17","author":"Sauter JL","year":"2022","unstructured":"Sauter JL, Dacic S, Galateau-Salle F, et al. The 2021 WHO classification of tumors of the pleura: advances since the 2015 classification. J Thorac Oncol Off Publ Int Assoc Study Lung Cancer. 2022;17(5):608\u2010622.","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"key":"e_1_3_2_19_2","first-page":"374960","article-title":"Malignant mesothelioma presenting as a gradually enlarging pneumothorax","volume":"2013","author":"Prasad A","year":"2013","unstructured":"Prasad A, Olsen D, Sriram PS. Malignant mesothelioma presenting as a gradually enlarging pneumothorax. Case Rep Pulmonol. 2013;2013:374960.","journal-title":"Case Rep Pulmonol"},{"issue":"6","key":"e_1_3_2_20_2","first-page":"899","article-title":"Malignant mesothelioma in situ: clinical and pathologic implications","volume":"15","author":"Churg A","year":"2020","unstructured":"Churg A, Dacic S, Galateau-Salle F, Attanoos R, de Perrot M. Malignant mesothelioma in situ: clinical and pathologic implications. J Thorac Oncol Off Publ Int Assoc Study Lung Cancer. 2020;15(6):899\u2010901.","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.06.010"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231167492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231167492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231167492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:09:25Z","timestamp":1787645365000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231167492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1177\/10668969231167492"],"URL":"https:\/\/doi.org\/10.1177\/10668969231167492","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,1]]}}}