{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:39:49Z","timestamp":1791221989666,"version":"4.1.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background.<\/jats:italic>\n                    Lipomas are common superficial soft tissue tumors of mature adipocytes. In contrast, well-differentiated\/dedifferentiated liposarcoma typically presents in the retroperitoneum as large masses. We provide clinicopathologic and follow-up details of 9 retroperitoneal\/intra-abdominal benign lipomatous tumors (BLT) and discuss the utility of ancillary fluorescence in situ hybridization (FISH) in distinguishing from their malignant counterparts.\n                    <jats:italic toggle=\"yes\">Design.<\/jats:italic>\n                    Clinicopathologic details and histology of 9 intra-abdominal and retroperitoneal lipomas were studied along with ancillary CD10 immunohistochemistry (IHC) and FISH for\n                    <jats:italic toggle=\"yes\">MDM2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">CDK4<\/jats:italic>\n                    amplification.\n                    <jats:italic toggle=\"yes\">Results.<\/jats:italic>\n                    There were 6 females and 3 males. Median age at diagnosis was 52 years (range 36-81 years). Seven were identified incidentally and 2 presented with primary complaints. On imaging, 7 were considered suspicious for liposarcoma. Grossly, the tumors ranged from 3.4 to 41.2\u2005cm (median 16.5\u2005cm). Histologically, all cases showed well-differentiated BLT, further classified as lipoma (n\u2009=\u20097; 1 with metaplastic ossification, 2 with prominent vessels, and 4 ordinary lipomas) and lipoma-like hibernoma (n\u2009=\u20092)\u2014the latter 2 showed intramuscular lesions with interspersed brown fat. CD10 IHC showed strong staining in the 2 hibernomas, whereas the staining was weak in the remaining.\n                    <jats:italic toggle=\"yes\">MDM2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">CDK4<\/jats:italic>\n                    amplification were negative by FISH in all. Follow-up (median 18 months) did not show recurrence on clinical or imaging evaluation.\n                    <jats:italic toggle=\"yes\">Conclusion.<\/jats:italic>\n                    Retroperitoneal\/intra-abdominal BLT are extremely rare and are indistinguishable clinically and radiographically from liposarcoma. This necessitates molecular confirmation even when the histology is convincingly benign, for a confident diagnosis. Our cohort shows that conservative excision without removal of abutted organs is sufficient in most cases.\n                  <\/jats:p>","DOI":"10.1177\/10668969231167511","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T01:46:07Z","timestamp":1683078367000},"page":"46-57","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Intra-Abdominal and Retroperitoneal Benign Lipomatous Tumors\u2014An Extremely Rare Mimic of Liposarcoma and its Diagnostic Challenge"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-5074","authenticated-orcid":false,"given":"Faizan","family":"Malik","sequence":"first","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Allbee","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Soft Tissue and Bone Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020","unstructured":"WHO Classification of Tumours Editorial Board. 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