{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:29:02Z","timestamp":1787646542383,"version":"build-2736575974"},"reference-count":8,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                    Adamantinoma-like Ewing sarcoma (ALES) is a newly described rare entity, which shows\n                    <jats:italic toggle=\"yes\">EWSR1::FLI1<\/jats:italic>\n                    rearrangement characteristic of Ewing sarcoma. This can be diagnostically challenging as it manifests histologically with epithelial differentiation and has diffuse keratin expression as well as p40 and p60 positivity. We hereby report a case of ALES in a 33-year-old woman with a past medical history of breast carcinoma who presented with a right-sided parotid mass. CT scan of the neck showed a heterogenous mass within the superficial lobe, measuring 17\u2005mm in diameter for which the patient underwent superficial parotidectomy. Histopathology of the mass revealed a malignant neoplasm formed of solid nests, cords and sheets of cells with minimal cytoplasm and monomorphic nuclei with granular chromatin and indistinct nucleoli. Brisk mitotic activity and tumor necrosis were also present. The tumor showed strong and diffuse reactivity for pankeratin (clone AE1\/AE3) and keratin 20, both in a dot-like pattern, raising the suspicion of metastatic Merkel cell carcinoma; however, molecular studies showed\n                    <jats:italic toggle=\"yes\">EWSR1::FLI1<\/jats:italic>\n                    rearrangement, supporting the diagnosis of ALES. In summary, it is prudent to have knowledge about this entity to avoid its misdiagnosis as other malignancies of the head and neck region which exhibit a different clinical course, prognosis and hence treatment modalities.\n                  <\/jats:p>","DOI":"10.1177\/10668969231167523","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T03:43:30Z","timestamp":1682999010000},"page":"115-118","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Adamantinoma-Like Ewing Sarcoma Mimicking Merkel Cell Carcinoma in the Parotid Gland: A Diagnostic Pitfall"],"prefix":"10.1177","volume":"32","author":[{"given":"Kasturi","family":"Saikia","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8468-7695","authenticated-orcid":false,"given":"Fatimah I.","family":"Alruwaii","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Henry Ford Health, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjay","family":"Chitale","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-8751","authenticated-orcid":false,"given":"Khaleel I.","family":"Al-Obaidy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000167056.13614.62"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001171"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000460"},{"issue":"5","key":"e_1_3_2_5_2","first-page":"3230","article-title":"DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma","volume":"14","author":"Bailly RA","unstructured":"Bailly RA, Bosselut R, Zucman J, et al. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol. May 1994;14(5):3230\u20103241.","journal-title":"Mol Cell Biol"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Lind\u00e9n M Vannas C \u00d6sterlund T et al. FET fusion oncoproteins interact with BRD4 and SWI\/SNF chromatin remodelling complex subtypes in sarcoma. Mol Oncol. Jul 2022; 16(13):2470\u20132495.","DOI":"10.1002\/1878-0261.13195"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5752"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","unstructured":"Becker JC Stang A DeCaprio JA et al. Merkel cell carcinoma. Nat Rev Dis Primers. Oct 26 2017;3:17077.","DOI":"10.1038\/nrdp.2017.77"},{"issue":"12","key":"e_1_3_2_9_2","article-title":"Adamantinoma-Like ewing sarcoma of the parotid gland: report of two cases and review of literature","volume":"12","author":"Alnuaim H","unstructured":"Alnuaim H, Alzahrani M, Ghandurah S, Dababo M. Adamantinoma-Like ewing sarcoma of the parotid gland: report of two cases and review of literature. Cureus. Dec 3 2020;12(12):e11870.","journal-title":"Cureus"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231167523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231167523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231167523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:08:48Z","timestamp":1787645328000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231167523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,2]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1177\/10668969231167523"],"URL":"https:\/\/doi.org\/10.1177\/10668969231167523","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,2]]}}}