{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:27:10Z","timestamp":1787646430884,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016650","name":"Rare Diseases Clinical Research Network","doi-asserted-by":"publisher","award":["NIH U54 NS115054"],"award-info":[{"award-number":["NIH U54 NS115054"]}],"id":[{"id":"10.13039\/100016650","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                    Thymomas are tumors of the mediastinum often associated with autoimmune conditions, in particular myasthenia gravis. In contrast, among the fewer than 40 reports of metaplastic thymoma, myasthenia gravis is rarely found. We describe the fourth patient, and first man, with metaplastic thymoma and myasthenia gravis. A 34-year-old had acute onset of double vision with associated dysphagia and was found to have an elevation of serum acetylcholine receptor antibodies. He underwent a transsternal thymectomy. Tissue sections showed a biphasic proliferation of keratin-positive epithelial cells with a complement of spindle cells confirming the diagnosis of metaplastic thymoma. Terminal deoxynucleotidyl transferase (TDT)-positive T lymphocytes were rare and only found in the periphery of the tumor, consistent with thymic remnant. A\n                    <jats:italic toggle=\"yes\">YAP1::MAML2<\/jats:italic>\n                    gene fusion, with an in-frame fusion between genes\n                    <jats:italic toggle=\"yes\">YAP1<\/jats:italic>\n                    Exon5 (NM_001130145) and\n                    <jats:italic toggle=\"yes\">MAML2<\/jats:italic>\n                    Exon2 (NM_032427) was found, supporting further the diagnosis of metaplastic thymoma (Anchored multiplex RNA sequencing [Archer Dx, Boulder, CO] assay). The patient's gender and relatively young age, the presence of an autoimmune condition, and the lack of lymphocytic infiltrate all contribute unusual features to this case and suggest avenues for further exploration.\n                  <\/jats:p>","DOI":"10.1177\/10668969231168344","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T13:04:25Z","timestamp":1682341465000},"page":"155-159","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Rare Case of Metaplastic Thymoma Presenting With Myasthenia Gravis"],"prefix":"10.1177","volume":"32","author":[{"given":"Ilianne","family":"Vega Prado","sequence":"first","affiliation":[{"name":"The George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2733-0398","authenticated-orcid":false,"given":"John","family":"Shymansky","sequence":"additional","affiliation":[{"name":"The George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha","family":"Apte","sequence":"additional","affiliation":[{"name":"The George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Mortman","sequence":"additional","affiliation":[{"name":"The George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"Kaminski","sequence":"additional","affiliation":[{"name":"The George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Barak","sequence":"additional","affiliation":[{"name":"The George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.12.108"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000482"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.11.118"},{"key":"e_1_3_2_5_2","unstructured":"Who classification of tumours online. WHO Website Web site. https:\/\/tumourclassification.iarc.who.int\/chaptercontent\/35\/225. 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Metaplastic thymoma with myasthenia gravis presumably caused by an accumulation of intratumoral immature T cells: a case report. 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