{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:30:40Z","timestamp":1787646640821,"version":"build-2736575974"},"reference-count":12,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                    Lymphoplasmacytic lymphoma often needs to be differentiated from other B-cell lymphomas with plasmacytic differentiation, especially marginal zone cell lymphoma. Molecular detection of\n                    <jats:italic toggle=\"yes\">MYD88<\/jats:italic>\n                    p.L265P hotspot mutation supports the diagnosis of lymphoplasmacytic lymphoma since it is seen in about 90% of such lymphoma, which is much higher than other B-cell lymphomas.\n                    <jats:italic toggle=\"yes\">MYD88<\/jats:italic>\n                    p.L265P is a gain-of-function mutation that enhances the activity of the NF-\u03baB signaling pathway and therefore drives lymphomagenesis. Other mutations in\n                    <jats:italic toggle=\"yes\">MYD88<\/jats:italic>\n                    are rarely reported. This study aims to report an unusual\n                    <jats:italic toggle=\"yes\">MYD88<\/jats:italic>\n                    in-frame deletion in an aggressive lymphoplasmacytic neoplasm. This is an IgM-positive, CD5- and CD10-negative mature B-cell lymphoma with prominent plasmacytic differentiation and aggressive features. The clinical and pathologic findings were most consistent with lymphoplasmacytic lymphoma. Next-generation sequencing identified an unusual\n                    <jats:italic toggle=\"yes\">MYD88<\/jats:italic>\n                    in-frame deletion in the absence of the hotpot p.L265P mutation. Other concurrent pathogenic mutations also include truncating mutations of\n                    <jats:italic toggle=\"yes\">TRAF3<\/jats:italic>\n                    , which is a negative regulator of the NF-\u03baB signaling pathway, and a missense mutation of\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    . Karyotype analysis showed complex karyotypes, including chromosome 6q deletion. By searching literature and online cancer databases, we identified only 8 other mature B-cell lymphomas with\n                    <jats:italic toggle=\"yes\">MYD88<\/jats:italic>\n                    in-frame deletions, but none of them was diagnosed with lymphoplasmacytic lymphoma. Recognizing such in-frame deletions is necessary to help understand the mutational spectrum of\n                    <jats:italic toggle=\"yes\">MYD88<\/jats:italic>\n                    in B-cell lymphomas. It remains to be further investigated whether such\n                    <jats:italic toggle=\"yes\">MYD88<\/jats:italic>\n                    in-frame deletions are also overrepresented in lymphoplasmacytic lymphoma among other B-cell lymphomas.\n                  <\/jats:p>","DOI":"10.1177\/10668969231168359","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T13:04:36Z","timestamp":1682341476000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Aggressive Lymphoplasmacytic Neoplasm With an Unusual In-frame Deletion of\n                    <i>MYD88<\/i>\n                    Associated With\n                    <i>TRAF3<\/i>\n                    and\n                    <i>TP53<\/i>\n                    Mutations and Complex Karyotype"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-5986","authenticated-orcid":false,"given":"Mingfei","family":"Yan","sequence":"first","affiliation":[{"name":"University Hospitals Cleveland Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Meyerson","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwadwo A.","family":"Oduro","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashirekha","family":"Shetty","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Yoest","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0215"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(96)01506-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22590-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-573188"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1754"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09176.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1015"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0151"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503262200"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3701"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15560"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0007"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231168359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231168359","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231168359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:08:52Z","timestamp":1787645332000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231168359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,24]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1177\/10668969231168359"],"URL":"https:\/\/doi.org\/10.1177\/10668969231168359","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,24]]}}}