{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:32:27Z","timestamp":1787646747888,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background.<\/jats:italic>\n                    Fibroadenoma (FA) and benign phyllodes tumor (PT) of the breast often have similar appearances on imaging. While an exact diagnosis of biopsy specimens is required to choose adequate treatment, including surgical procedures, it is sometimes difficult to pathologically differentiate these 2 tumors due to histological resemblances. To elucidate markers for distinguishing FA from benign PT, we analyzed clinical samples immunohistochemically.\n                    <jats:italic toggle=\"yes\">Methods.<\/jats:italic>\n                    We retrospectively investigated 80 breast fibroepithelial lesions. As a discovery set, 60 surgical excision samples (30 FA and 30 benign PT) were examined. Twenty biopsy samples (10 FA and 10 benign PT) were examined as a validation set. To determine targets for immunohistochemistry, we first tested some proteins based on previous reports. As a result, Ki67 was chosen for differentiating FA and PT; thus further examinations were conducted with this protein.\n                    <jats:italic toggle=\"yes\">Results.<\/jats:italic>\n                    Among the proteins examined, stromal Ki67 was significantly higher in PT than in FA. Benign PT had significantly higher stromal Ki67 expression both at random and at hotspots (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.001 and &lt;.001, respectively). The receiver operating characteristic curve analysis identified 3.5% and 8.5% (at random spots and hotspots, respectively) as the optimal cutoff values of stromal Ki67 for distinguishing between these 2 tumors. In the validation cohort employing needle biopsy specimens, we confirmed that these 2 cutoff values properly classified these 2 tumors (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.043 and .029, respectively).\n                    <jats:italic toggle=\"yes\">Conclusion.<\/jats:italic>\n                    We revealed that stromal Ki67 might be a potential marker for distinguishing FA from benign PT.\n                  <\/jats:p>","DOI":"10.1177\/10668969231171132","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T02:38:14Z","timestamp":1683599894000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Stromal Ki67 Expression Might be a Useful Marker for Distinguishing Fibroadenoma From Benign Phyllodes Tumor of the Breast"],"prefix":"10.1177","volume":"32","author":[{"given":"Men","family":"Yuan","sequence":"first","affiliation":[{"name":"Juntendo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumi","family":"Saeki","sequence":"additional","affiliation":[{"name":"Juntendo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-0768","authenticated-orcid":false,"given":"Yoshiya","family":"Horimoto","sequence":"additional","affiliation":[{"name":"Juntendo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Ishizuka","sequence":"additional","affiliation":[{"name":"Juntendo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Onagi","sequence":"additional","affiliation":[{"name":"Juntendo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsue","family":"Saito","sequence":"additional","affiliation":[{"name":"Juntendo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Juntendo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Juntendo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[{"name":"Juntendo University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0443-RA"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2017.05.006"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0692-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-019-0588-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2014.73"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14316"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-10931-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.745242"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13749"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000444377"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2019-206208"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-203590"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2015.01.003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12712"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.5333"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3409"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.326"},{"issue":"1","key":"e_1_3_3_19_2","article-title":"Role of CD10 immunoexpression in grading phyllodes tumour of the breast","volume":"11","author":"Kulkarni MM","year":"2017","unstructured":"Kulkarni MM, Khandeparkar SG, Joshi AR, et al. Role of CD10 immunoexpression in grading phyllodes tumour of the breast. J Clin Diagn Res. 2017;11(1):Ec14\u2010ec16.","journal-title":"J Clin Diagn Res"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.020917"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.177215"},{"issue":"1","key":"e_1_3_3_22_2","first-page":"133","article-title":"AgNOR, Ki-67 and PCNA expression in fibroepithelial tumours of the breast in correlation with morphological features","volume":"63","author":"Barwijuk-Macha\u0142a M","year":"2004","unstructured":"Barwijuk-Macha\u0142a M, Musiatowicz B, Cylwik J, Resze\u0107 J, Augustynowicz A. AgNOR, Ki-67 and PCNA expression in fibroepithelial tumours of the breast in correlation with morphological features. 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