{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:43:22Z","timestamp":1792611802966,"version":"4.5.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Sinonasal glomangiopericytoma is an uncommon mesenchymal tumor with a perivascular myoid phenotype, which is categorized as a borderline\/low-grade malignant soft tissue tumor by the current World Health Organization Classification of Head and Neck tumors. Here, we present the case of a 53-year-old woman with an unusual spindle cell morphology of sinonasal glomangiopericytoma arising in the nasal cavity, mimicking solitary fibrous tumor. Microscopically, the tumor showed a cellular proliferation of spindle cells in fascicles including a focal long sweeping arrangement or whorls, or with a storiform growth pattern, associated with hemangiopericytoma-like gaping blood vessels embedded in a fibrous stroma. This arrangement of the spindle cells faintly indicated a solitary fibrous tumor rather than sinonasal glomangiopericytoma. Immunohistochemically, the tumor was positively reactive to not only beta-catenin (in the nuclei) but also CD34, although signal transducers and activators of transcription 6 was negative. Mutational analysis using Sanger sequencing detected a CTNNB1 mutation. We finally diagnosed the tumor as a sinonasal glomangiopericytoma, showing an unusual spindle cell variant. Such unusual spindle cell morphology with CD34-immunoreactivity potentially leads to an incorrect diagnosis of solitary fibrous tumor because such prominent fascicles including long sweeping structures, reminiscent of desmoid-type fibromatosis, have scarcely been described in the literature. Hence, careful morphological scrutiny using appropriate diagnostic adjuncts is necessary for correct diagnosis.<\/jats:p>","DOI":"10.1177\/10668969231177889","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:01:57Z","timestamp":1686193317000},"page":"408-413","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["CD34-Positive Spindle Cell Tumor With\n                    <i>CTNNB1<\/i>\n                    Mutation: An Unusual Spindle Cell Variant of Sinonasal Glomangiopericytoma"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-4594","authenticated-orcid":false,"given":"Ryuji","family":"Iwamura","sequence":"first","affiliation":[{"name":"University of Occupational and Environmental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Nawata","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Akaike","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, School of Medicine, Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, School of Medicine, Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Hisaoka","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"WHO Classification of Head and Neck Tumors","author":"El-Naggar AK","year":"2017","unstructured":"El-Naggar AK, Chan JKC, Grandis JR, et al. 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